一项关于新型自体牙骨移植材料在鼻窦骨移植手术中有效性的前瞻性研究。
A prospective study on the effectiveness of newly developed autogenous tooth bone graft material for sinus bone graft procedure.
机构信息
Department of Oral and Maxillofacial Surgery, Section of Dentistry, Korea University Anam Hospital, Seoul, Republic of Korea.
Department of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea. ; Department of Dentistry & Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
出版信息
J Adv Prosthodont. 2014 Dec;6(6):528-38. doi: 10.4047/jap.2014.6.6.528. Epub 2014 Dec 17.
PURPOSE
The purpose of this prospective study was to evaluate the effectiveness of newly developed autogenous tooth bone graft material (AutoBT)application for sinus bone graft procedure.
MATERIALS AND METHODS
The patients with less than 5.0 mm of residual bone height in maxillary posterior area were enrolled. For the sinus bone graft procedure, Bio-Oss was grafted in control group and AutoBT powder was grafted in experimental group. Clinical and radiographic examination were done for the comparison of grafted materials in sinus cavity between groups. At 4 months after sinus bone graft procedure, biopsy specimens were analyzed by microcomputed tomography and histomorphometric examination for the evaluation of healing state of bone graft site.
RESULTS
In CT evaluation, there was no difference in bone density, bone height and sinus membrane thickness between groups. In microCT analysis, there was no difference in total bone volume, new bone volume, bone mineral density of new bone between groups. There was significant difference trabecular thickness (0.07 µm in Bio-Oss group Vs. 0.08 µm in AutoBT group) (P=.006). In histomorphometric analysis, there was no difference in new bone formation, residual graft material, bone marrow space between groups. There was significant difference osteoid thickness (8.35 µm in Bio-Oss group Vs. 13.12 µm in AutoBT group) (P=.025).
CONCLUSION
AutoBT could be considered a viable alternative to the autogenous bone or other bone graft materials in sinus bone graft procedure.
目的
本前瞻性研究旨在评估新开发的自体牙骨移植材料（AutoBT）在鼻窦骨移植中的应用效果。
材料和方法
纳入上颌后区剩余骨高度小于 5.0 毫米的患者。对于鼻窦骨移植术，对照组中移植 Bio-Oss，实验组中移植 AutoBT 粉末。通过临床和影像学检查比较两组鼻窦腔内移植材料的情况。在鼻窦骨移植术后 4 个月，通过 microCT 分析和组织形态计量学检查对骨移植部位的愈合状态进行评估，分析活检标本。
结果
在 CT 评估中，两组间的骨密度、骨高度和窦膜厚度无差异。在 microCT 分析中，两组间总骨体积、新骨体积、新骨骨密度无差异。但在小梁厚度方面有显著差异（Bio-Oss 组为 0.07 µm，AutoBT 组为 0.08 µm）（P=.006）。在组织形态计量学分析中，两组间新骨形成、残留移植物、骨髓腔无差异。但在类骨质厚度方面有显著差异（Bio-Oss 组为 8.35 µm，AutoBT 组为 13.12 µm）（P=.025）。
结论
AutoBT 可被视为鼻窦骨移植术自体骨或其他骨移植材料的可行替代品。
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