Abul-Hajj Y J, Iverson R, Kiang D T
Steroids. 1979 Feb;33(2):205-22. doi: 10.1016/0039-128x(79)90027-8.
The metabolism of dehydroepiandrosterone and testosterone by human mammary tumor was investigated. Estrogen synthesis from dehydroepiandrosterone was observed in 9 of 10 estrogen-receptor-negative tumors and only in 2 of 8 receptor-positive tumors (p less than 0.025). Conversion of testosterone to estrogens was observed in 7 of 8 receptor-negative and 2 of 7 receptor-positive tumors. Tumors which are capable of transforming dehydroepiandrosterone to estrogens were also able to aromatize testosterone suggesting that the presence of the aromatase enzyme is inherent to certain tumor cells. No estrogen formation was detected by the mitochondrial-microsomal fraction of normal breast cells while fractions from both fat cell and tumor cell showed estrogen synthesis. Estrogen formation by tumor cell fraction ranged from 5 to 190 times that observed for fat cells. The physiological significance of these results in the neoplastic tissue and its relationship to hormone dependence are discussed.
研究了人乳腺肿瘤对脱氢表雄酮和睾酮的代谢情况。在10个雌激素受体阴性肿瘤中有9个观察到了由脱氢表雄酮合成雌激素的现象，而在8个受体阳性肿瘤中仅有2个出现此现象（p小于0.025）。在8个受体阴性肿瘤中有7个以及7个受体阳性肿瘤中有2个观察到了睾酮向雌激素的转化。能够将脱氢表雄酮转化为雌激素的肿瘤也能够使睾酮芳香化，这表明芳香化酶的存在是某些肿瘤细胞所固有的。正常乳腺细胞的线粒体 - 微粒体部分未检测到雌激素生成，而脂肪细胞和肿瘤细胞的部分均显示有雌激素合成。肿瘤细胞部分的雌激素生成量是脂肪细胞的5至190倍。讨论了这些结果在肿瘤组织中的生理意义及其与激素依赖性的关系。
