Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents.
作者信息
Yadav Prem P, Gupta Prasoon, Chaturvedi A K, Shukla P K, Maurya Rakesh
机构信息
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
出版信息
Bioorg Med Chem. 2005 Mar 1;13(5):1497-505. doi: 10.1016/j.bmc.2004.12.032.
Abstract
Synthesis of nitrogen and sulfur heterocyclic mimics of furanoflavonoids have been achieved for the first time. Synthesized flavonoid alkaloids and thiophenyl flavonoids have been screened for antifungal and antibacterial activities. All the test compounds barring 25 exhibited antifungal activity. The compound 19 was the best and showed comparable MICs to the known compound karanjin. Compounds 5, 12, 14 and 22 also showed comparable MIC to karanjin.
摘要
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