Zimet Gregory D, Mays Rose M, Sturm Lynne A, Ravert April A, Perkins Susan M, Juliar Beth E
Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA.
Arch Pediatr Adolesc Med. 2005 Feb;159(2):132-7. doi: 10.1001/archpedi.159.2.132.
To evaluate parental attitudes about adolescent vaccination as a function of vaccine characteristics, including whether the vaccine prevented a sexually transmitted infection (STI), and to explore possible sociodemographic predictors of acceptability of STI vaccines.
Participants were 278 parents who accompanied their children (69.1% female, aged 12-17 years) to appointments at medical clinics. By using computer-based questionnaires, parents rated 9 hypothetical vaccine scenarios, each of which was defined along 4 dimensions: mode of transmission (STI or non-STI), severity of infection (curable, chronic, or fatal), vaccine efficacy (50%, 70%, or 90%), and availability of behavioral methods for prevention (available or not available). Willingness by parents to vaccinate their adolescents under each vaccine scenario was assessed on a scale that ranged from 0 to 100. Conjoint analysis was used to determine the relative contribution of each dimension to the ratings.
The mean vaccine scenario rating was 81.3. Sexually transmitted infection vaccines (mean, 81.3) were not rated differently than non-STI vaccines (mean, 80.0). Conjoint analysis indicated that severity of infection and vaccine efficacy had the strongest influence on ratings, followed by availability of behavioral prevention. Mode of transmission had a negligible effect on ratings. Child age (P = .08) and sex (P = .77), parent age (P = .32) and education (P = .34), insurance status (P = .08), and data collection site (P = .48) were not significantly associated with STI vaccine acceptability.
Parents were accepting of the idea of vaccinating their adolescent children against STIs. The most salient issues were severity of infection and vaccine efficacy, not sexual transmissibility. Parents also favored vaccines for infections that had no method of behavioral prevention available.
评估父母对青少年接种疫苗的态度与疫苗特性之间的关系,包括疫苗是否能预防性传播感染(STI),并探索性传播感染疫苗可接受性的可能社会人口学预测因素。
278名陪同孩子(69.1%为女性,年龄在12至17岁之间)前往医疗诊所就诊的家长参与了研究。通过基于计算机的问卷,家长对9种假设的疫苗情景进行评分,每个情景沿着4个维度定义:传播方式(性传播感染或非性传播感染)、感染严重程度(可治愈、慢性或致命)、疫苗效力(50%、70%或90%)以及预防行为方法的可用性(有或无)。根据从0到100的量表评估家长在每种疫苗情景下为其青少年接种疫苗的意愿。采用联合分析来确定每个维度对评分的相对贡献。
疫苗情景的平均评分为81.3。性传播感染疫苗(平均分为81.3)与非性传播感染疫苗(平均分为80.0)的评分没有差异。联合分析表明,感染严重程度和疫苗效力对评分的影响最大,其次是预防行为的可用性。传播方式对评分的影响可忽略不计。孩子的年龄(P = 0.08)和性别(P = 0.77)、家长的年龄(P = 0.32)和教育程度(P = 0.34)、保险状况(P = 0.08)以及数据收集地点(P = 0.48)与性传播感染疫苗的可接受性没有显著关联。
父母接受为其青少年子女接种预防性传播感染疫苗的想法。最突出的问题是感染严重程度和疫苗效力,而非性传播性。父母也更倾向于为那些没有行为预防方法的感染接种疫苗。