Wang Bing, Chen Gang, Ratcliffe Julie, Afzali Hossein Haji Ali, Giles Lynne, Marshall Helen
The Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
PLoS One. 2017 Jul 26;12(7):e0181073. doi: 10.1371/journal.pone.0181073. eCollection 2017.
The importance of adolescent engagement in health decisions and public health programs such as immunisation is becoming increasingly recognised. Understanding adolescent preferences and further identifying barriers and facilitators for immunisation acceptance is critical to the success of adolescent immunisation programs. This study applied a discrete choice experiment (DCE) to assess vaccination preferences in adolescents.
This study was conducted as a cross-sectional, national online survey in Australian adolescents. The DCE survey evaluated adolescent vaccination preferences. Six attributes were assessed including disease severity, target for protection, price, location of vaccination provision, potential side effects and vaccine delivery method. A mixed logit model was used to analyse DCE data.
This survey was conducted between December 2014 and January 2015. Of 800 adolescents aged 15 to 19 years, stronger preferences were observed overall for: vaccination in the case of a life threatening illness (p<0.001), lower price vaccinations (p<0.001), mild but common side effects (p = 0.004), delivery via a skin patch (p<0.001) and being administered by a family practitioner (p<0.001). Participants suggested that they and their families would be willing to pay AU$394.28 (95%CI: AU$348.40 to AU$446.92) more for a vaccine targeting a life threatening illness than a mild-moderate illness, AU$37.94 (95%CI: AU$19.22 to AU$57.39) more for being vaccinated at a family practitioner clinic than a council immunisation clinic, AU$23.01 (95%CI: AU$7.12 to AU$39.24) more for common but mild and resolving side effects compared to rare but serious side effects, and AU$51.80 (95%CI: AU$30.42 to AU$73.70) more for delivery via a skin patch than injection.
Consideration of adolescent preferences may result in improved acceptance of, engagement in and uptake of immunisation programs targeted for this age group.
青少年参与健康决策以及诸如免疫接种等公共卫生项目的重要性日益得到认可。了解青少年的偏好，并进一步确定影响免疫接种接受度的障碍和促进因素，对于青少年免疫接种项目的成功至关重要。本研究应用离散选择实验（DCE）来评估青少年的疫苗接种偏好。
本研究作为一项横断面全国在线调查，在澳大利亚青少年中开展。DCE调查评估了青少年的疫苗接种偏好。评估了六个属性，包括疾病严重程度、保护对象、价格、疫苗接种地点、潜在副作用和疫苗接种方式。使用混合逻辑回归模型分析DCE数据。
本调查于2014年12月至2015年1月进行。在800名15至19岁的青少年中，总体上观察到对以下方面有更强的偏好：在危及生命的疾病情况下接种疫苗（p<0.001）、价格较低的疫苗接种（p<0.001）、轻微但常见的副作用（p = 0.004）、通过皮肤贴片接种（p<0.001）以及由家庭医生接种（p<0.001）。参与者表示，与针对轻度至中度疾病的疫苗相比，他们及其家人愿意为针对危及生命疾病的疫苗多支付394.28澳元（95%CI：348.40澳元至446.92澳元）；与市政免疫接种诊所相比，在家庭医生诊所接种疫苗愿意多支付37.94澳元（95%CI：19.22澳元至57.39澳元）；与罕见但严重的副作用相比，对于常见但轻微且可缓解的副作用愿意多支付23.01澳元（95%CI：7.12澳元至39.24澳元）；与注射方式相比，通过皮肤贴片接种愿意多支付51.80澳元（95%CI：30.42澳元至73.70澳元）。
考虑青少年的偏好可能会提高该年龄组免疫接种项目的接受度、参与度和接种率。
