使用蛋白质链接浏览器（PLEX）进行蛋白质功能预测。
Protein function prediction using the Protein Link EXplorer (PLEX).
作者信息
Date Shailesh V, Marcotte Edward M
机构信息
Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, 1 University Station, A4800, Austin, TX 78712-1064, USA.
出版信息
Bioinformatics. 2005 May 15;21(10):2558-9. doi: 10.1093/bioinformatics/bti313. Epub 2005 Feb 8.
UNLABELLED
We introduce the Protein Link EXplorer (PLEX), a web-based environment that allows the construction of a phylogenetic profile for any given amino acid sequence, and its comparison with profiles of approximately 350,000 predicted genes from 89 genomes, as a means of interactively identifying functionally linked genes and predicting protein function. PLEX can be searched iteratively and also enables searches for chromosomal gene neighbors and Rosetta Stone linkages. PLEX search results are accompanied by quantitative estimates of linkage confidence, enabling users to take advantage of coinheritance, operon and gene fusion-based methods for inferring gene function and reconstructing cellular systems and pathways.
AVAILABILITY
未标注
我们引入了蛋白质链接探索器（PLEX），这是一个基于网络的环境，它允许为任何给定的氨基酸序列构建系统发育谱，并将其与来自89个基因组的约350,000个预测基因的谱进行比较，以此作为交互式识别功能相关基因和预测蛋白质功能的一种手段。PLEX可以进行迭代搜索，还能搜索染色体上的基因邻居和罗塞塔石碑式的联系。PLEX搜索结果会附带联系置信度的定量估计，使用户能够利用基于共遗传、操纵子和基因融合的方法来推断基因功能以及重建细胞系统和途径。
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