Prilusky Jaime, Felder Clifford E, Zeev-Ben-Mordehai Tzviya, Rydberg Edwin H, Man Orna, Beckmann Jacques S, Silman Israel, Sussman Joel L
Biological Services, Weizmann Institute of Science, Rehovot 76100, Israel.
Bioinformatics. 2005 Aug 15;21(16):3435-8. doi: 10.1093/bioinformatics/bti537. Epub 2005 Jun 14.
An easy-to-use, versatile and freely available graphic web server, FoldIndex is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.
本文介绍了一种易于使用、多功能且免费的图形网络服务器FoldIndex：它通过实施基于序列平均残基疏水性和净电荷的乌韦尔斯基及其同事的算法，预测给定蛋白质序列是否为内在无序。FoldIndex的错误率与更复杂的折叠预测方法相当。滑动窗口允许识别蛋白质内具有与整个蛋白质不同折叠倾向的大区域。
