来自拟大戟的两种新的二萜聚酯。

Two new diterpene polyesters from Euphorbia decipiens.

作者信息

Ahmad Viqar Uddin, Hussain Javid, Hussain Hidayat, Farooq Umar, Lodhi M Arif, Choudhary M Iqbal

机构信息

H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.

出版信息

Nat Prod Res. 2005 Apr;19(3):267-74. doi: 10.1080/14786410410001714687.

DOI:10.1080/14786410410001714687

PMID:15702640

Abstract

Two new myrsinol-type diterpene polyesters 3,5,13,17-tetra-O-acetyl-7-O-benzoyl-15-hydroxymyrsinol (1) and 3,5,13,17-tetra-O-acetyl-7-O-butanoyl-13-hydroxymyrsinol (2), with a tricyclic carbon skeleton have been isolated from Euphorbia decipiens Boiss. & Buhse. The structure elucidation of the isolated compounds was based primarily on HREIMS, EIMS, IR, UV, ID-, and 2D-NMR analyses, including COSY, HMQC, HMBC, and NOESY correlations. Compounds 1 and 2 also showed activity against urease enzyme.

摘要

从拟大戟（Euphorbia decipiens Boiss. & Buhse.）中分离出了两种具有三环碳骨架的新型肉豆蔻醇型二萜聚酯，即3,5,13,17-四-O-乙酰基-7-O-苯甲酰基-15-羟基肉豆蔻醇（1）和3,5,13,17-四-O-乙酰基-7-O-丁酰基-13-羟基肉豆蔻醇（2）。所分离化合物的结构解析主要基于高分辨电子轰击质谱（HREIMS）、电子轰击质谱（EIMS）、红外光谱（IR）、紫外光谱（UV）、一维和二维核磁共振（NMR）分析，包括化学位移相关谱（COSY）、异核多量子相干谱（HMQC）、异核多键相关谱（HMBC）和核Overhauser效应谱（NOESY）相关。化合物1和2对脲酶也表现出活性。