Blaiss Michael S
University of Tennessee Health Science Center, Germantown, TN 38138, USA.
Curr Med Res Opin. 2004 Dec;20(12):1937-52. doi: 10.1185/030079904x13266.
Allergic rhinitis (AR) can have substantial negative impact on children. Most notably, it can impede learning during the school-age years. Other consequences include adverse behavioral and psychosocial effects, poor quality of life, and potential impact on serious comorbidities, such as asthma.
In February 2004, in a conference sponsored by Aventis Pharmaceuticals, a multidisciplinary group convened to review relevant clinical data for the purposes of developing consensus recommendations for the management of AR in children. The consensus panel consisted of academic, school health, and medical providers, who were identified based on previous work and publications.
The focus of discussions was to assess the degree of impact of AR in schoolchildren and, based on this information, to determine how to improve screening, diagnosis, prevention, and treatment, to help ensure quality of life and maximal school performance in this population. The group considered the most critical factor in successful management ot be communication and collaboration among parents, educators, and healthcare professionals. Knowledge of the common signs and symptoms of AR in children can help to ensure early diagnosis, appropriate intervention, and clinically favorable outcomes. Importantly, both uncontrolled symptoms of AR, as well as adverse effects from medications, can diminish cognitive function and learning. When choosing treatment for children with AR, consideration must be given to the side effects of medications. All first-generation and some second-generation antihistamines can be associated with adverse effects on cognitive function and learning, as a result of their sedative properties. Treatment with non-sedating second-generation antihistamine has been shown to improve learning potential and is an ideal choice for treatment in this population.
Existing data indicate that further studies using objective measures of impairment in children taking antihistamine medications should be conducted to evaluate the impact of disease and treatment.
变应性鼻炎(AR)会对儿童产生重大负面影响。最显著的是,它会在学龄期阻碍学习。其他后果包括不良行为和心理社会影响、生活质量差以及对严重合并症(如哮喘)的潜在影响。
2004年2月,在赛诺菲安万特制药公司赞助的一次会议上,一个多学科小组召开会议,审查相关临床数据,目的是就儿童AR的管理制定共识性建议。共识小组由学术、学校卫生和医疗服务提供者组成,他们是根据以前的工作和出版物确定的。
讨论的重点是评估AR对学童的影响程度,并根据这些信息确定如何改进筛查、诊断、预防和治疗,以帮助确保该人群的生活质量和最佳学习表现。该小组认为成功管理的最关键因素是家长、教育工作者和医疗保健专业人员之间的沟通与协作。了解儿童AR的常见体征和症状有助于确保早期诊断、适当干预和临床良好结果。重要的是,AR的未控制症状以及药物的不良反应都会降低认知功能和学习能力。在为AR儿童选择治疗方法时,必须考虑药物的副作用。所有第一代和一些第二代抗组胺药由于其镇静特性,可能会对认知功能和学习产生不良反应。使用非镇静性第二代抗组胺药治疗已被证明可以提高学习潜力,是该人群治疗的理想选择。
现有数据表明,应进行进一步研究,采用客观指标衡量服用抗组胺药物儿童的损害情况,以评估疾病和治疗的影响。