Byakika-Tusiime J, Oyugi J H, Tumwikirize W A, Katabira E T, Mugyenyi P N, Bangsberg D R
Makerere University School of Medicine, Kampala and Academic Alliance for AIDS Care and Prevention in Africa, Kampala, Uganda.
Int J STD AIDS. 2005 Jan;16(1):38-41. doi: 10.1258/0956462052932548.
Our objective was to determine the level of adherence and reasons for non-adherence to antiretroviral therapy (ART) among HIV-positive (HIV+) people on ART in a resource-limited setting. Patients receiving ART were recruited into the cross-sectional study from three treatment centres in Kampala, Uganda. The number of missed doses over the last three days was assessed by structured patient interviews and dichotomized at +/-95% adherence. Reasons for non-adherence were assessed with both structured patient interviews and unstructured qualitative interviews. Independent predictors of non-adherence were assessed with multivariate logistic regression. In all, 304 HIV-infected persons on ART were enrolled into the study. Factors associated with non-adherence were marital status (odds ratio (OR) = 2.93, 95% confidence interval (CI) 1.32-6.50) and low monthly income <50 US$ [OR = 2.77, 95% CI 1.64-4.67]. We concluded that levels of self-reported adherence in patients receiving ART in Kampala are comparable to levels in resource-rich settings with inability to purchase and secure a stable supply as a major barrier to adherence.
我们的目标是确定在资源有限的环境中，接受抗逆转录病毒疗法（ART）的HIV阳性（HIV+）患者的治疗依从性水平及不依从的原因。从乌干达坎帕拉的三个治疗中心招募接受ART的患者进入这项横断面研究。通过结构化的患者访谈评估过去三天内漏服药物的次数，并将依从性分为+/-95%进行二分法分析。通过结构化的患者访谈和非结构化的定性访谈评估不依从的原因。使用多变量逻辑回归评估不依从的独立预测因素。总共304名接受ART的HIV感染者被纳入研究。与不依从相关的因素包括婚姻状况（优势比（OR）=2.93，95%置信区间（CI）1.32 - 6.50）和月收入低<50美元[OR = 2.77，95%CI 1.64 - 4.67]。我们得出结论，坎帕拉接受ART治疗的患者自我报告的依从性水平与资源丰富环境中的水平相当，无法购买和确保稳定供应是依从性的主要障碍。
