de S Luna J, dos Santos A F, de Lima M R F, de Omena M C, de Mendonça F A C, Bieber L W, Sant'Ana A E G
Departamento de Química Fundamental-CCEN, Universidade Federal de Pernambuco, 50740-901 Recife PE, Brazil.
J Ethnopharmacol. 2005 Feb 28;97(2):199-206. doi: 10.1016/j.jep.2004.10.004. Epub 2005 Jan 4.
In a search for natural products that could be used to control the vectors of tropical diseases, 23 extracts of medicinal plants from the northeast of Brazil have been tested for molluscicidal activity against egg masses and adults of the snail Biomphalaria glabrata, for larvicidal activity against the larvae of the mosquito Aedes aegypti, and for general toxicity against the larvae of the brine shrimp Artemia salina. Of these extracts, two were active against the adult snail, one against snail egg masses, eight against the larvae of the mosquito, and 16 showed toxicity towards the brine shrimp. Chemical tests indicated that a wide variety of natural product classes were present in those extracts that showed significant activities in the bioassays.
为寻找可用于控制热带病病媒的天然产物,对巴西东北部23种药用植物提取物进行了测试,检测其对光滑双脐螺卵块和成虫的杀螺活性、对埃及伊蚊幼虫的杀幼虫活性以及对卤虫无节幼体的一般毒性。在这些提取物中,两种对成年螺有活性,一种对螺卵块有活性,八种对蚊子幼虫有活性,16种对卤虫有毒性。化学测试表明,在生物测定中表现出显著活性的提取物中存在多种天然产物类别。