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[一组年轻患者中脊柱穿刺后头痛的发生率]

[The incidence of post spinal headache in a group of young patients].

作者信息

Frenkel C, Altscher T, Groben V, Hörnchen U

机构信息

Institut für Anästhesiologie der Rheinischen Friedrich Wilhelms-Universität Bonn.

出版信息

Anaesthesist. 1992 Mar;41(3):142-5.

PMID:1570887
Abstract

Post-dural puncture headache (PDPH) is a significant and well-known complication of procedures that perforate the dura mater, e.g., clinical spinal anaesthesia (SpA). The exact mechanisms leading to PDPH are still not completely understood, although several factors, particularly the patient's age, modulate the incidence. In young patients (20-30 years) previous studies reported high occurrences of PDPH in 6%-16% of cases [5, 8], decreasing the value and acceptance of SpA in this patient group. This study was undertaken to reevaluate under reproducible study conditions the incidence of PDPH and other side effects due to SpA in a larger and more homogeneous patient group. METHODS. Two hundred and two male patients between 19 and 30 years of age were included in this study. The standard anaesthetic technique consisted of oral premedication (1 mg flunitrazepam), preanaesthetic intravenous hydration with at least 0.5 l Ringer's lactate, monitoring of vital signs, and a standard lumbar puncture (lateral position, L2/3 or L3/4 interspace, 25-gauge spinal needle, parallel bevel direction). Anaesthesia was achieved using 12.5 mg hyperbaric 0.5% bupivacaine. Anaesthetic level, onset, and duration (pinprick method) and intraoperative events were recorded. Patients were randomly immobilised for either 6 or 24 h postoperatively. Patients were visited on the 2nd, 4th, and 7th postoperative day to ascertain the occurrence of PDPH and further anaesthesia-related complications. RESULTS. The 202 patients studied had homogeneous demographic characteristics (Table 1). During surgery (average duration: 36 min +/- 18; 10-100 min) with satisfactory anaesthetic levels 1 patient demonstrated a high spinal block (T1). Intraoperatively, a significant decrease in blood pressure was noted in 5 patients (2.5%) and bradycardia in 24 (11.9%). Ten minutes after local anaesthetic instillation the sensory block reached an average level of T10 and had ascended to T8 after 25 minutes (start of surgery). During the three postanaesthetic visits PHPD was present in 7 cases (3.5%); 3 other patients had non-PDPH "tension" headaches (1.5%). All PDPHs occurred on the first 2 postoperative days with a maximum duration of 4 days (1 patient). Treatment consisted of bed rest, hydration, and/or oral analgesics. No patient developed any neurologic sequelae. Moderate back pain (12.4%) and urinary retention (2.5%) were the other postoperative complications. The duration of prophylactic postoperative immobilisation had no obvious impact on PDPH occurrence. Our patients' acceptance of SpA was very high; 98.5% of them would favour SpA for future surgery. DISCUSSION. In contrast to previous studies reporting a high incidence of PDPH (6%-16%) in young adults, we found, in a stringent investigation of a large number of comparable patients in a defined age group, a PDPH rate of 3.5% and a few other minor side effects together with good anaesthetic quality, intraoperative stability, and excellent patient acceptance. Although future studies are needed to further minimise SpA complications, we found SpA a safe anaesthetic technique in our well-defined patient group.

摘要

硬膜穿刺后头痛(PDPH)是硬膜穿孔操作(如临床脊髓麻醉(SpA))的一种重要且广为人知的并发症。尽管有几个因素,特别是患者年龄,会影响其发生率,但导致PDPH的确切机制仍未完全明确。在年轻患者(20 - 30岁)中,既往研究报道PDPH发生率在6% - 16%[5, 8],这降低了该患者群体对SpA的接受度和认可度。本研究旨在通过可重复的研究条件,重新评估在更大且更同质化患者群体中SpA导致的PDPH及其他副作用的发生率。方法:本研究纳入了202名年龄在19至30岁之间的男性患者。标准麻醉技术包括口服术前用药(1毫克氟硝西泮)、术前静脉输注至少0.5升乳酸林格氏液、生命体征监测以及标准腰椎穿刺(侧卧位,L2/3或L3/4椎间隙,25号脊髓穿刺针,斜面平行)。使用12.5毫克高压0.5%布比卡因实现麻醉。记录麻醉平面、起效时间、持续时间(针刺法)及术中情况。术后患者随机固定6小时或24小时。在术后第2天、第4天和第7天对患者进行访视,以确定PDPH及其他与麻醉相关并发症的发生情况。结果:研究的202例患者具有同质化的人口统计学特征(表1)。手术期间(平均持续时间:36分钟±18;10 - 100分钟),麻醉平面满意,1例患者出现高位脊髓阻滞(T1)。术中,5例患者(2.5%)出现显著血压下降,24例患者(11.9%)出现心动过缓。局部麻醉药注入10分钟后,感觉阻滞平均达到T10平面,25分钟(手术开始)后升至T8平面。在三次麻醉后访视中,7例患者(3.5%)出现PDPH;另外3例患者有非PDPH“紧张性”头痛(1.5%)。所有PDPH均发生在术后头2天,最长持续4天(1例患者)。治疗包括卧床休息、补液和/或口服镇痛药。无患者出现任何神经后遗症。中度背痛(12.4%)和尿潴留(2.5%)是其他术后并发症。术后预防性固定时间对PDPH发生无明显影响。我们的患者对SpA的接受度非常高;98.5%的患者愿意在未来手术中选择SpA。讨论:与既往报道年轻成年人中PDPH发生率较高(6% - 16%)的研究不同,我们在对大量特定年龄组的可比患者进行的严格调查中发现,PDPH发生率为3.5%,还有一些其他轻微副作用,同时具有良好的麻醉质量、术中稳定性和患者高接受度。尽管需要进一步研究以进一步减少SpA并发症,但我们发现在我们明确界定的患者群体中,SpA是一种安全的麻醉技术。

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