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[类风湿关节炎的多学科治疗。疼痛体验的统计学及临床变化]

[Multidisciplinary treatment rheumatoid arthritis. Statistical and clinical change in pain experience].

作者信息

Klages U

机构信息

Poliklinik für Kieferorthopädie, Klinikum der Johannes-Gutenberg-Universität Mainz.

出版信息

Schmerz. 2005 Feb;19(1):26-39. doi: 10.1007/s00482-004-0322-6.

DOI:10.1007/s00482-004-0322-6
PMID:15712005
Abstract

INTRODUCTION

To date only few studies have been reported on the effect of multidisciplinary inpatient treatment on pain experience in patients with rheumatoid arthritis (RA). Aims of the present research were: to asses the development of different pain qualities at the beginning, at the end of treatment and at a follow-up three months later in a RA-patient sample as a whole, to determine statistically and clinically significant changes on individual base, and to study pain coping behaviors as predictive and pain-change associated variables.

METHODS

Subjects were 66 patients with a diagnosis of RA. They were treated with non-steroidal antiphlogistic and disease modifying drugs as well as with physical therapy. Measurement instruments were the pain experience scale with 5 subtests, the four-dimensional questionnaire of pain behavior, the functional disability scale, and a joint-index.

RESULTS

At follow-up the reduction was strongest in the quality of persistent pain experience (effect size d: 0.54). Among sensory components a marked reduction was found for the experience of thermal pain. A statistically and clinically reliable change was assessed in 18% of he RA-patients, further 26% indicated a statistical only change. 33% remained stable at a functional level of pain experience. 12% did not change a high level of pain, and 11% deteriorated. Change in the coping behaviors of avoidance and support were associated with success in pain reduction.

CONCLUSION

In the assessment of patient improvement different qualities of pain experience should be taken into account. It was suggested that inpatient multidisciplinary treatment was beneficial with regard to pain reduction in nearly on half of the RA-patients. The coping behaviors of avoidance and social support deserve attention as pain change associated variables.

摘要

引言

迄今为止,关于多学科住院治疗对类风湿性关节炎(RA)患者疼痛体验的影响,仅有少数研究报道。本研究的目的是:评估在整个RA患者样本中,不同疼痛性质在治疗开始时、治疗结束时以及三个月后的随访中的变化情况,在个体层面确定具有统计学和临床意义的变化,并研究疼痛应对行为作为预测变量和与疼痛变化相关的变量。

方法

研究对象为66例确诊为RA的患者。他们接受了非甾体抗炎药、病情缓解抗风湿药以及物理治疗。测量工具包括具有5个分测试的疼痛体验量表、疼痛行为四维问卷、功能残疾量表和关节指数。

结果

随访时,持续性疼痛体验的减轻最为明显(效应量d:0.54)。在感觉成分中,热痛体验有显著减轻。在18%的RA患者中评估出具有统计学和临床可靠性的变化,另有26%仅显示有统计学上的变化。33%在疼痛体验的功能水平上保持稳定。12%的患者疼痛水平没有变化,11%的患者病情恶化。回避和支持的应对行为变化与疼痛减轻的成功与否相关。

结论

在评估患者的改善情况时,应考虑不同性质的疼痛体验。研究表明,住院多学科治疗对近一半的RA患者减轻疼痛有益。回避和社会支持的应对行为作为与疼痛变化相关的变量值得关注。

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