[Expression of CD30 in nasal mucosa of patients with allergic rhinitis].

OBJECTIVE

To study the role of CD30 in the pathogenesis of allergic rhinitis.

METHOD

The specimens of thirty-one patients with allergic rhinitis and twenty-six control subjects were studied by immunohistochemical method to detect CD30 cell. A mean numbers of positive cells per high field (10 x 40) were counted. All data were analyzed with t-test.

RESULT

The number of CD30+ cells in the nasal mucosa of patients with allergic rhinitis was significantly more than that in the controls (P < 0.05).

CONCLUSION

This study suggests a T-helper 2-dominated mucosal reaction in the allergic rhinitis compared to the nonallergic groups,and the expression level of CD30 can reflect the T-helper 2-dominated mucosal reaction.