Russo F, Linsalata M, Messa C, Cavallini A, Notarnicola M, Guerra V, Lantone G, Lacatena M, Di Leo A
Laboratorio di Biochimica, IRCCS S de Bellis Castellana Grotte, Bari, Italy.
Ital J Gastroenterol. 1992 Jan;24(1):8-12.
We assayed the estrogen receptors and polyamine levels (putrescine, spermidine and spermine) in the neoplastic and "normal" surrounding tissue of patients with colorectal cancer. Polyamine levels and the spermidine/spermine ratio were significantly higher in the neoplastic tissue than in the "normal" surrounding colonic mucosa of the same patients. Estrogen receptors were fewer in neoplastic mucosa than in the surrounding tissue, and polyamine levels were higher in estrogen-receptor negative tumours than in estrogen-receptor positive ones, although this was statistically significant only in the case of spermidine. Polyamine levels and estrogen receptor concentrations did not correlate with the tumour site, histological differentiation, or the age and sex of patients.
我们检测了结肠癌患者肿瘤组织及周围“正常”组织中的雌激素受体和多胺水平（腐胺、亚精胺和精胺）。肿瘤组织中的多胺水平及亚精胺/精胺比值显著高于同一患者周围的“正常”结肠黏膜。肿瘤黏膜中的雌激素受体少于周围组织，雌激素受体阴性肿瘤中的多胺水平高于雌激素受体阳性肿瘤，不过仅亚精胺的这种差异具有统计学意义。多胺水平和雌激素受体浓度与肿瘤部位、组织学分化以及患者的年龄和性别均无关联。
