Hixson L J, Garewal H S, McGee D L, Sloan D, Fennerty M B, Sampliner R E, Gerner E W
Department of Internal Medicine, University of Arizona, Tucson 85724.
Cancer Epidemiol Biomarkers Prev. 1993 Jul-Aug;2(4):369-74.
Ornithine decarboxylase (ODC) and polyamines are intimately involved in normal cellular proliferation and are likely to play a role in carcinogenesis. ODC activity and polyamine content were measured in tissue samples obtained during colonoscopy from 48 benign neoplastic polyps (20 tubular adenomas; 28 villous adenomas), 18 cancers (including 5 malignant polyps), and adjacent mucosa. ODC activity in polyp and cancer tissue specimens was higher than in adjacent mucosa in 75 and 83% of pairs, respectively. Similarly, putrescine, spermidine, and spermine contents were higher in the majority of polyps and cancers compared to adjacent mucosa. ODC activity and polyamine content in colonic mucosa from 10 patients without a history of colorectal neoplasia were not different from adjacent mucosal values in the patients with neoplasia. In conclusion, ODC and polyamines are elevated in the majority of colorectal neoplasms, but amounts in normal mucosa do not differentiate between patients with cancer, benign neoplastic polyps, and normal subjects.
鸟氨酸脱羧酶（ODC）和多胺与正常细胞增殖密切相关，且可能在致癌过程中发挥作用。在结肠镜检查期间从48个良性肿瘤性息肉（20个管状腺瘤；28个绒毛状腺瘤）、18例癌症（包括5个恶性息肉）及相邻黏膜获取的组织样本中，检测了ODC活性和多胺含量。息肉和癌组织标本中的ODC活性分别在75%和83%的样本对中高于相邻黏膜。同样，与相邻黏膜相比，大多数息肉和癌症中的腐胺、亚精胺和精胺含量更高。10例无结直肠肿瘤病史患者的结肠黏膜中的ODC活性和多胺含量与有肿瘤患者的相邻黏膜值无差异。总之，大多数结直肠肿瘤中ODC和多胺水平升高，但正常黏膜中的含量在癌症患者、良性肿瘤性息肉患者和正常受试者之间并无差异。
