Naso Pietro, Lanteri Raffaele, Acquaviva Rosaria, Licata Francesca, Bonanno Giacomo, Licata Antonio
Department of Surgical Sciences, Organ Transplantation and Advanced Technologies, University of Catania, Catania, Italy.
Hepatogastroenterology. 2005 Mar-Apr;52(62):433-6.
BACKGROUND/AIMS: The aim of this study is to evaluate free polyamine and acetyl derivate levels in colorectal cancer, precancerous lesions and a control group in order to investigate if there are different concentrations between neoplastic and non-neoplastic lesions.
For this study, in the Department of Surgical Sciences of Catania University we observed 62 patients affected by colorectal cancer, 32 affected by precancerous lesions and 20 used as the control group. In each patient we performed an endoscopic biopsy on the lesion, one 5 cm to the lesion and one 10 cm to the lesion. In each biopsy were detected polyamines concentrations.
We found a significant increment of free and acetylated polyamines levels in neoplastic patients in comparison with non-neoplastic. Polyamines levels are increased at the site of cancer in comparison of adjacent colonic mucosa. In addition polyamines levels are increased in normal colon mucosa from cancer patients compared with the mucosa of control patients.
Significant increment of polyamines levels at the site of cancer in comparison of non-neoplastic mucosa and adjacent colonic mucosa give them the possibility to occupy an important role in early detection of colon cancer by acting like oncological markers.
背景/目的：本研究旨在评估结直肠癌、癌前病变及对照组中的游离多胺和乙酰化衍生物水平，以调查肿瘤性病变与非肿瘤性病变之间是否存在不同浓度。
在卡塔尼亚大学外科科学系，我们对62例结直肠癌患者、32例癌前病变患者及20例作为对照组的患者进行了观察。对每位患者的病变处、病变处近端5 cm及10 cm处进行内镜活检。检测每份活检组织中的多胺浓度。
我们发现肿瘤患者中游离和乙酰化多胺水平与非肿瘤患者相比显著升高。与相邻结肠黏膜相比，癌灶部位的多胺水平升高。此外，与对照患者的黏膜相比，癌症患者正常结肠黏膜中的多胺水平也升高。
与非肿瘤性黏膜及相邻结肠黏膜相比，癌灶部位的多胺水平显著升高，这使它们有可能作为肿瘤标志物在结肠癌的早期检测中发挥重要作用。
