MMWR Morb Mortal Wkly Rep. 2005 Feb 18;54(6):141-4.
Hepatitis A vaccine was first licensed in the United States in 1995. In 1996, the Advisory Committee on Immunization Practices (ACIP) recommended vaccination of children aged >/=24 months in populations with the highest incidence of hepatitis A (e.g., American Indian/Alaska Native [AI/AN], Asian/Pacific Islander, and selected Hispanic and religious communities). In 1999, these guidelines were expanded to recommend routine vaccination for children residing in 11 states where average annual hepatitis A incidence during 1987-1997 was at least 20 per 100,000 population (twice the national average) and to consider routine vaccination for children in six states where average annual incidence was 10-20 per 100,000 population. This report is the first national analysis of hepatitis A vaccination coverage among children. The results indicate that, in 2003, vaccination coverage levels with at least 1 dose of hepatitis A vaccine for children aged 24-35 months varied from 6.4% to 72.7% in areas where routine vaccination is recommended. In addition, hepatitis A vaccination coverage rates for children aged 24-35 months are lower than overall rates for other vaccines recommended for children. Sustaining and improving vaccination coverage among young children is needed to ensure continued declines in hepatitis A incidence in the United States.
甲型肝炎疫苗于1995年在美国首次获得许可。1996年,免疫实践咨询委员会(ACIP)建议对甲型肝炎发病率最高的人群中24个月及以上的儿童进行疫苗接种(例如,美国印第安人/阿拉斯加原住民[AI/AN]、亚太岛民以及部分西班牙裔和宗教社区)。1999年,这些指南得到扩展,建议对居住在11个州的儿童进行常规疫苗接种,这些州在1987 - 1997年期间甲型肝炎的年均发病率至少为每10万人20例(是全国平均水平的两倍),并考虑对年均发病率为每10万人10 - 20例的6个州的儿童进行常规疫苗接种。本报告是对儿童甲型肝炎疫苗接种覆盖率的首次全国性分析。结果表明,2003年,在建议进行常规疫苗接种的地区,24至35个月大儿童至少接种1剂甲型肝炎疫苗的接种覆盖率从6.4%到72.7%不等。此外,24至35个月大儿童的甲型肝炎疫苗接种覆盖率低于推荐给儿童的其他疫苗的总体接种率。为确保美国甲型肝炎发病率持续下降,需要维持并提高幼儿的疫苗接种覆盖率。