Savitz Sean I, Dinsmore Jonathan H, Wechsler Lawrence R, Rosenbaum Daniel M, Caplan Louis R
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
NeuroRx. 2004 Oct;1(4):406-14. doi: 10.1602/neurorx.1.4.406.
Increasing experimental evidence suggests that cell transplantation can enhance recovery from stroke in animal models of focal cerebral ischemia. Clinical trials have been investigating the effects of a human immortalized neuronal cell line and porcine fetal neurons in stroke victims with persistent and stable deficits. Preclinical studies are focusing on the effects of human stem cells from various sources including brain, bone marrow, umbilical cord, and adipose tissue. This review presents an overview of preclinical and clinical studies on cell therapy for stroke. We emphasize the current, limited knowledge about the biology of implant sources and discuss special conditions in stroke that will impact the potential success of neurotransplantation in clinical trials.
越来越多的实验证据表明，在局灶性脑缺血动物模型中，细胞移植可促进中风后的恢复。临床试验一直在研究一种人类永生化神经元细胞系和猪胎儿神经元对患有持续性和稳定性缺陷的中风患者的影响。临床前研究主要关注来自各种来源（包括脑、骨髓、脐带和脂肪组织）的人类干细胞的作用。本综述概述了中风细胞治疗的临床前和临床研究。我们强调了目前关于植入源生物学的有限知识，并讨论了中风中的特殊情况，这些情况将影响神经移植在临床试验中的潜在成功率。
