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阳离子型多面体低聚倍半硅氧烷（POSS）单元作为药物递送过程的载体。

Cationic polyhedral oligomeric silsesquioxane (POSS) units as carriers for drug delivery processes.

作者信息

McCusker Catherine, Carroll Joseph B, Rotello Vincent M

机构信息

Department of Chemistry, The University of Massachusetts, Amherst, MA 01003, USA.

出版信息

Chem Commun (Camb). 2005 Feb 28(8):996-8. doi: 10.1039/b416266h. Epub 2005 Jan 10.

DOI:10.1039/b416266h
PMID:15719094
Abstract

Quaternary ammonium functionalized polyhedral oligomeric silsesquioxane (OctaAmmonium-POSS) units, widely employed as additives in ceramic and polymeric systems, possess many attributes which make them attractive as biocompatible drug carriers: nanoscale size, three-dimensional functionality, efficient cellular uptake, low toxicity, and high solubility.

摘要

季铵官能化的多面体低聚倍半硅氧烷（八铵基-POSS）单元，在陶瓷和聚合物体系中广泛用作添加剂，具有许多使其成为有吸引力的生物相容性药物载体的特性：纳米级尺寸、三维功能性、高效的细胞摄取、低毒性和高溶解性。

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