School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, PR China.
School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, PR China.
Biomaterials. 2015 Jul;55:12-23. doi: 10.1016/j.biomaterials.2015.03.034. Epub 2015 Apr 9.
In this work, a star-shaped polymer consisting of a cationic poly[2-(dimethylamino) ethyl methacrylate] (PDMAEMA) shell and a zwitterionic poly[N-(3-(methacryloylamino) propyl)-N,N-dimethyl-N-(3-sulfopropyl) ammonium hydroxide] (PMPD) corona was grafted from a polyhedral oligomeric silsesquioxanes (POSS)-based initiator via atomic transfer radical polymerization (ATRP). The reported star-shaped polymer could form stable micelles in aqueous solutions even in the presence of serum. In addition, anti-cancer drug doxorubicin and tumor-suppressing p53 gene were loaded in the process of micelle formation. The formed polyplex was biocompatible and highly efficient for both drug and gene delivery. Furthermore, the polyplex was able to cause a high apoptotic rate of tumor cells both in vitro and in vivo. This combination delivery strategy offers a promising method for cancer therapy and can be used for further clinical applications.
在这项工作中，通过原子转移自由基聚合（ATRP），从基于多面体低聚倍半硅氧烷（POSS）的引发剂上接枝了一种由阳离子聚[2-（二甲氨基）乙基甲基丙烯酸酯]（PDMAEMA）壳和两性离子聚[N-（3-（丙烯酰基氨基）丙基）-N，N-二甲基-N-（3-磺丙基）铵氢氧化物]（PMPD）冠组成的星形聚合物。所报道的星形聚合物即使在存在血清的情况下也能在水溶液中形成稳定的胶束。此外，在胶束形成过程中负载了抗癌药物阿霉素和抑癌基因 p53。形成的聚轮烷具有良好的生物相容性，对药物和基因的传递都非常高效。此外，聚轮烷在体外和体内均能使肿瘤细胞产生高凋亡率。这种组合递药策略为癌症治疗提供了一种有前途的方法，可用于进一步的临床应用。
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