Hoseini Leila, Roozbeh Jamshid, Sagheb Mehdi, Karbalay-Doust Saied, Noorafshan Ali
Internal Medicine Department, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Micron. 2009 Feb;40(2):226-30. doi: 10.1016/j.micron.2008.08.004. Epub 2008 Sep 11.
Anabolic androgenic steroids are widely used by athletes for increasing their muscle mass. These drugs are also used by some patients with chronic renal disease. But the effect of these drugs on the renal structure has received less attention. To investigate which parts of the kidney are affected by these drugs, mice kidneys were studied stereologically after injection of nandrolone decanoate (ND), an anabolic androgenic steroid. The treated group received nandrolone decanoate intraperitoneally (solved in olive oil) in doses of 3mg/kg of body weight and administered in one, two and three doses, respectively, in the first, second and third week of treatment. The mice in the control group received an olive oil solution. One week after the last injection, the mice were anaesthetized and their kidney removed. The analysis of data revealed that the weight of kidney was increased approximately 30% (p < or = 0.006) and its volume increased approximately 25% (p < or = 0.02) in ND treated mice in comparison with the control group. The volume of the cortex increased in ND treated animals approximately 44% (p < or = 0.006). Proximal convoluted tubules (PCT) and distal convoluted tubules (DCT) volume increased approximately 25% (p < or = 0.02) and approximately 68% (p < or = 0.02) in ND treated mice. The volume of glomeruli, other ducts, connective tissues, vessels and the length of PCT, DCT, collecting and Henle's ducts and vessels did not show significant differences.
ND can increase the volume of the renal cortex and its two main parts, i.e. PCT and DCT in mice.
合成代谢雄激素类固醇被运动员广泛用于增加肌肉量。一些慢性肾病患者也使用这些药物。但这些药物对肾脏结构的影响较少受到关注。为了研究肾脏的哪些部位受这些药物影响，在注射合成代谢雄激素类固醇癸酸诺龙（ND）后，对小鼠肾脏进行了体视学研究。治疗组腹腔注射癸酸诺龙（溶于橄榄油），剂量为3mg/kg体重，分别在治疗的第一、第二和第三周注射一、二和三次。对照组小鼠接受橄榄油溶液。最后一次注射一周后，将小鼠麻醉并摘除肾脏。数据分析显示，与对照组相比，ND处理的小鼠肾脏重量增加约30%（p≤0.006），体积增加约25%（p≤0.02）。ND处理的动物皮质体积增加约44%（p≤0.006）。ND处理的小鼠近端曲管（PCT）和远端曲管（DCT）体积分别增加约25%（p≤0.02）和约68%（p≤0.02）。肾小球、其他管道、结缔组织、血管以及PCT、DCT、集合管和亨氏管及血管的长度没有显著差异。
ND可增加小鼠肾皮质及其两个主要部分即PCT和DCT的体积。
