Olas Beata, Wachowicz Barbara, Stochmal Anna, Oleszek Wieslaw
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland.
Nutrition. 2005 Feb;21(2):199-206. doi: 10.1016/j.nut.2004.03.024.
Yucca schidigera is a plant that grows in Mexico, and it has a very high level of saponins and phenolic compounds with antioxidant action. The products of Y. schidigera are used as food additives and have a generally recognized as safe label. This study investigated the antiplatelet mechanisms of four phenolic compounds.
We investigated antiplatelet mechanisms of the phenolic compounds trans-3,4',5-trihydroxystilbene (trans-resveratrol), trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene, and yuccaols A and C that had been isolated from the bark of Y. schidigera by studying their effects on the first step of platelet activation, i.e., platelet adhesion to collagen and fibrinogen. The effects of these compounds on the release of adenine nucleotides, proteins, and beta-N-acetyl-glycosaminidase (a marker of lysosomal secretion) from blood platelets activated by thrombin were also studied.
These different phenolic compounds (1 to 25 microg/mL) and their extracts decreased platelet adhesion and secretion.
Resveratrol and yucca extract were more reactive in decreasing these processes than were other tested phenolic compounds.
丝兰是一种生长在墨西哥的植物，其皂苷和酚类化合物含量很高，具有抗氧化作用。丝兰产品用作食品添加剂，并有普遍公认安全标识。本研究调查了四种酚类化合物的抗血小板机制。
我们通过研究从丝兰树皮中分离出的酚类化合物反式-3,4',5-三羟基芪（反式白藜芦醇）、反式-3,3',5,5'-四羟基-4'-甲氧基芪以及丝兰醇A和C对血小板激活第一步（即血小板与胶原蛋白和纤维蛋白原的黏附）的影响，来研究其抗血小板机制。还研究了这些化合物对凝血酶激活的血小板中腺嘌呤核苷酸、蛋白质和β-N-乙酰氨基葡萄糖苷酶（溶酶体分泌标志物）释放的影响。
这些不同的酚类化合物（1至25微克/毫升）及其提取物可降低血小板黏附和分泌。
白藜芦醇和丝兰提取物在减少这些过程方面比其他测试的酚类化合物更具活性。
