Johnson Jeffrey A, Luo Nan, Shaw James W, Kind Paul, Coons Stephen Joel
Institute of Health Economics and University of Alberta, Edmonton, Alberta, Canada.
Med Care. 2005 Mar;43(3):221-8. doi: 10.1097/00005650-200503000-00004.
We sought to compare directly elicited valuations for EQ-5D health states between the US and UK general adult populations.
We analyzed data from 2 EQ-5D valuation studies where, using similar time trade-off protocols, values for 42 common health states were elicited from representative samples of the US and UK general adult populations. First, US and UK population mean valuations were estimated and compared for each health state. Second, random-effect models were used to compare the US and UK valuations while adjusting for known predictors of EQ-5D valuations (ie, age, sex, health state descriptors) and to investigate whether and how the valuations differ.
Population mean valuations of the 42 health states ranged from -0.38 to 0.88 for the United States and from -0.54 to 0.88 for the United Kingdom, with the US mean scores being numerically higher than the UK for 39 health states (mean difference: 0.11; range: -0.01 to 0.25). After adjusting for the main effects of known predictors, the average difference in valuations was 0.10 (P < 0.001). The magnitude of the difference in the US and UK valuations was not constant across EQ-5D health states; greater differences in valuations were present in health states characterized by extreme problems.
Meaningful differences exist in directly elicited TTO valuations of EQ-5D health states between the US and UK general populations. Therefore, EQ-5D index scores generated using valuations from the US general population should be used for studies aiming to reflect health state preferences of the US general public.
我们试图直接比较美国和英国普通成年人群对EQ-5D健康状态的估值。
我们分析了两项EQ-5D估值研究的数据，这两项研究使用了类似的时间权衡协议，从美国和英国普通成年人群的代表性样本中得出了42种常见健康状态的价值。首先，估计并比较美国和英国人群对每种健康状态的平均估值。其次，使用随机效应模型比较美国和英国的估值，同时调整EQ-5D估值的已知预测因素（即年龄、性别、健康状态描述符），并调查估值是否存在差异以及如何存在差异。
42种健康状态的人群平均估值在美国为-0.38至0.88，在英国为-0.54至0.88，其中39种健康状态的美国平均得分在数值上高于英国（平均差异：0.11；范围：-0.01至0.25）。在调整已知预测因素的主要影响后，估值的平均差异为0.10（P < 0.001）。美国和英国估值的差异幅度在EQ-5D健康状态中并非恒定不变；在以极端问题为特征的健康状态中，估值差异更大。
美国和英国普通人群对EQ-5D健康状态的直接得出的时间权衡估值存在显著差异。因此，使用美国普通人群估值生成的EQ-5D指数得分应用于旨在反映美国普通公众健康状态偏好的研究。
