Chen D T, Worrall B B, Brown R D, Brott T G, Kissela B M, Olson T S, Rich S S, Meschia J F
Department of Health Evaluation Sciences, University of Virginia, Charlottesville, USA.
Neurology. 2005 Feb 22;64(4):721-4. doi: 10.1212/01.WNL.0000152042.07414.CC.
The authors reviewed the recruitment of stroke-affected sibling pairs using a letter-based, proband-initiated contact strategy. The authors randomly sampled 99 proband enrollment forms (Phase 1) and randomly sampled 50 sibling reply cards (Phase 2). The sibling response rate was 30.6%, for a pedigree response rate of 58%. Of the siblings who replied, 96% authorized further contact. Median time from proband enrollment to pedigree DNA banking, which required 3+ probands, was 134 days.
作者采用基于信件、先证者发起的联系策略，回顾了中风患者同胞对的招募情况。作者随机抽取了99份先证者登记表（第一阶段），并随机抽取了50份同胞回复卡（第二阶段）。同胞回复率为30.6%，家系回复率为58%。在回复的同胞中，96%授权进一步联系。从先证者登记到家系DNA库建立（这需要3名以上先证者）的中位时间为134天。
