Rosburg Timm, Trautner Peter, Dietl Thomas, Korzyukov Oleg A, Boutros Nashaat N, Schaller Carlo, Elger Christian Erich, Kurthen Martin
Department of Epileptology, University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany.
Brain. 2005 Apr;128(Pt 4):819-28. doi: 10.1093/brain/awh442. Epub 2005 Feb 23.
Mismatch negativity (MMN) is elicited by discernible changes in an otherwise regular stream of auditory stimulation and reflects a pre-attentive detection mechanism. In the current study, auditory evoked potentials were recorded intracranially and electrode contacts sensitive for stimulus deviance were selected in order to further elucidate the contribution of different brain areas to MMN generation. Data were obtained from patients with frontal and temporal lobe epilepsy undergoing a presurgical evaluation by subdural and depth electrodes. In 13 of 29 patients under investigation an intracranial MMN could be observed, while in four other patients a response recovery of the N100 was revealed, mimicking an MMN. Most electrodes with an MMN signal were located in or close to the superior temporal lobe. In two patients an MMN was observed at electrode contacts over the lateral inferior frontal cortex and in one patient at a frontal interhemispheric electrode strip, giving evidence for a participation of the frontal gyrus in MMN generation. Current findings have, however, to be interpreted with caution owing to the placement and limited extension of the used electrode arrays.
失匹配负波（MMN）由原本规律的听觉刺激流中可察觉的变化引发，反映了一种前注意检测机制。在本研究中，通过颅内记录听觉诱发电位，并选择对刺激偏差敏感的电极触点，以进一步阐明不同脑区对MMN产生的贡献。数据来自接受硬膜下和深部电极术前评估的额叶和颞叶癫痫患者。在29例受调查患者中，13例可观察到颅内MMN，而另外4例患者显示N100反应恢复，类似于MMN。大多数有MMN信号的电极位于颞上叶或其附近。在2例患者中，在外侧额下回皮质的电极触点处观察到MMN，在1例患者中，在额叶半球间电极条处观察到MMN，这为额回参与MMN产生提供了证据。然而，由于所用电极阵列的放置和范围有限，目前的研究结果应谨慎解释。
