Berg Rune W, Friedman Beth, Schroeder Lee F, Kleinfeld David
Department of Physics 0374, University of California at San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.
J Neurophysiol. 2005 Jul;94(1):699-711. doi: 10.1152/jn.01125.2004. Epub 2005 Feb 23.
We tested the hypothesis that activation of nucleus basalis magnocellularis (NBM), which provides cholinergic input to cortex, facilitates motor control. Our measures of facilitation were changes in the direction and time-course of vibrissa movements that are elicited by microstimulation of vibrissa motor (M1) cortex. In particular, microstimulation led solely to a transient retraction of the vibrissae in the sessile animal but to a full motion sequence of protraction followed by retraction in the aroused animal. We observed that activation of NBM, as assayed by cortical desynchronization, induced a transition from microstimulation-evoked retraction to full sweep sequences. This dramatic change in the vibrissa response to microstimulation was blocked by systemic delivery of atropine and, in anesthetized animals, an analogous change was blocked by the topical administration of atropine to M1 cortex. We conclude that NBM significantly facilitates the ability of M1 cortex to control movements. Our results bear on the importance of cholinergic activation in schemes for neuroprosthetic control of movement.
向皮层提供胆碱能输入的大细胞基底核（NBM）的激活有助于运动控制。我们衡量促进作用的指标是对触须运动（M1）皮层进行微刺激所引发的触须运动方向和时间进程的变化。具体而言，微刺激在静止动物中仅导致触须短暂回缩，但在兴奋动物中则导致先伸出后回缩的完整运动序列。我们观察到，通过皮层去同步化测定的NBM激活诱导了从微刺激诱发的回缩到完整扫动序列的转变。对微刺激的触须反应的这种显著变化被全身注射阿托品所阻断，并且在麻醉动物中，向M1皮层局部施用阿托品也阻断了类似的变化。我们得出结论，NBM显著促进了M1皮层控制运动的能力。我们的结果说明了胆碱能激活在运动神经假体控制方案中的重要性。
