Langevin Stanley A, Brault Aaron C, Panella Nicholas A, Bowen Richard A, Komar Nicholas
Center for Vector-Borne Diseases, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616, USA.
Am J Trop Med Hyg. 2005 Jan;72(1):99-102.
The observation of avian mortality associated with West Nile virus (WNV) infection has become a hallmark epidemiologic feature in the recent emergence of this pathogen in Israel and North America. To determine if phenotypic differences exist among different WNV isolates, we exposed house sparrows (Passer domesticus) to low passage, lineage 1 WNV strains from North America (NY99), Kenya (KEN), and Australia (KUN; also known as Kunjin virus). House sparrows inoculated with the NY99 and KEN strains experienced similar mortality rates and viremia profiles. The KUN strain elicited significantly lower-titered viremia when compared with the other strains and induced no mortality. This study suggests that natural mortality in house sparrows due to Old World strains of WNV may be occurring where the KEN strain occurs.
在西尼罗河病毒（WNV）感染相关的鸟类死亡观察已成为该病原体近期在以色列和北美出现后的一个标志性流行病学特征。为确定不同WNV分离株之间是否存在表型差异，我们让家麻雀（Passer domesticus）接触来自北美的低代次1型WNV毒株（NY99）、肯尼亚毒株（KEN）和澳大利亚毒株（KUN；也称为库京病毒）。接种NY99和KEN毒株的家麻雀经历了相似的死亡率和病毒血症情况。与其他毒株相比，KUN毒株引发的病毒血症滴度显著更低，且未导致死亡。这项研究表明，在存在KEN毒株的地方，家麻雀可能会因旧世界WNV毒株而出现自然死亡情况。
