Soares Maria Cecília Bianchi, Paula Claudete Rodrigues, Dias Amanda L T, Caseiro Marcos Montani, Costa Sérgio Olavo Pinto da
Microbiology and Immunology Section, Adolfo Lutz Institute, Santos, São Paulo, Brazil.
Rev Inst Med Trop Sao Paulo. 2005 Jan-Feb;47(1):31-6. doi: 10.1590/s0036-46652005000100006. Epub 2005 Feb 23.
This study involved a total of 116 samples, 79 taken from pigeon droppings and 37 of atmospheric air taken close to accumulations of excrement. Cryptococcus neoformans var. grubii was isolated from 11 (13.9%) of these samples. Other species of Cryptococcus were also isolated from these samples, such as C. albidus (12.6%) and C. laurentii (8.9%). C. neoformans was not isolated from the air samples, though C. albidus (5.4%) was. All the strains of C. neoformans were found to belong to the A serotype (C. neoformans var. grubii). In regard to the studies with the antifungal agents 5-fluorocytosine, fluconazole, itraconazole, amphotericin B and voriconazole, by means of the microdilution method (EUCAST), we point out that one sample demonstrated resistance to fluconazole, this being especially significant because this is an environmental strain.
本研究共涉及116个样本，其中79个取自鸽粪，37个取自靠近粪便堆积处的大气空气。从这些样本中的11个（13.9%）分离出新型隐球菌格鲁比变种。还从这些样本中分离出其他隐球菌物种，如浅白隐球菌（12.6%）和罗伦隐球菌（8.9%）。空气样本中未分离出新型隐球菌，但分离出了浅白隐球菌（5.4%）。所有新型隐球菌菌株均属于A血清型（新型隐球菌格鲁比变种）。关于使用抗真菌剂5-氟胞嘧啶、氟康唑、伊曲康唑、两性霉素B和伏立康唑的研究，通过微量稀释法（欧洲抗菌药物敏感性试验委员会），我们指出有一个样本对氟康唑耐药，这一点尤为重要，因为这是一株环境菌株。
