Wallace Morgan E, Smyth Mark J
Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, 8006, East Melbourne, Victoria, Australia.
Springer Semin Immunopathol. 2005 Jun;27(1):49-64. doi: 10.1007/s00281-004-0195-x. Epub 2005 Feb 24.
Natural killer (NK) cells are the primary effector cells of the innate immune system and have a well-established role in tumor rejection in a variety of spontaneous and induced cancer models. NK cell function is regulated by a complex balance of inhibitory and activating signals that allow them to selectively target and kill cells that display an abnormal pattern of cell surface molecules, while leaving normal healthy cells unharmed. In this review we discuss NK cell function, the role of NK cells in cancer therapies, the emerging concept of bi-directional cross-talk between NK cells and dendritic cells, and the implications of these interactions for tumor immunotherapy.
自然杀伤（NK）细胞是先天性免疫系统的主要效应细胞，在多种自发和诱导性癌症模型的肿瘤排斥反应中发挥着既定作用。NK细胞的功能受抑制性和激活性信号的复杂平衡调节，这使它们能够选择性地靶向并杀死呈现异常细胞表面分子模式的细胞，同时使正常健康细胞免受伤害。在本综述中，我们讨论了NK细胞的功能、NK细胞在癌症治疗中的作用、NK细胞与树突状细胞之间双向串扰这一新兴概念，以及这些相互作用对肿瘤免疫治疗的影响。
