Brilot Fabienne, Strowig Till, Munz Christian
Laboratory of Viral Immunobiology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA.
Front Biosci. 2008 May 1;13:6443-54. doi: 10.2741/3165.
While natural killer (NK) cells received their name from their ability to mediate spontaneous cytotoxicity, it has recently become clear that they require activation to target most transformed and infected cells. Dendritic cells (DCs) have been shown to mediate NK cell activation during innate immune responses. Surprisingly, this interaction was recently reported to be required to restrict infections by NK cells, and to take place in secondary lymphoid organs. Here we review these recent studies on NK cell interactions with DCs, discuss the molecular mechanisms underlying the cross-talk between these two innate lymphocyte populations, and out-line how DCs and NK cells synergize to enhance innate immunity against microbes and tumors as well as shape the adaptive immune system. Based on this better understanding, we propose that NK cells should be targeted for their protective functions and as an adjuvant during immunotherapy development.
虽然自然杀伤（NK）细胞因其介导自发细胞毒性的能力而得名，但最近人们清楚地认识到，它们需要激活才能靶向大多数转化细胞和受感染细胞。在天然免疫反应过程中，树突状细胞（DC）已被证明可介导NK细胞的激活。令人惊讶的是，最近有报道称，这种相互作用是NK细胞限制感染所必需的，且发生在二级淋巴器官中。在此，我们综述了最近关于NK细胞与DC相互作用的研究，讨论了这两种天然淋巴细胞群体之间相互作用的分子机制，并概述了DC和NK细胞如何协同增强针对微生物和肿瘤的天然免疫以及塑造适应性免疫系统。基于这一更好的理解，我们建议在免疫治疗开发过程中，应针对NK细胞的保护功能并将其作为佐剂。
