Granucci Francesca, Zanoni Ivan, Pavelka Norman, Van Dommelen Serani L H, Andoniou Christopher E, Belardelli Filippo, Degli Esposti Mariapia A, Ricciardi-Castagnoli Paola
Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
J Exp Med. 2004 Aug 2;200(3):287-95. doi: 10.1084/jem.20040370.
Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required for optimal priming of NK cells. Type I interferons (IFNs) promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and in vivo for the efficient production of IFNgamma, which has an important antimetastatic and antibacterial function. These findings provide new information about the mechanisms that mediate DC-NK cell interactions and define a novel and fundamental role for IL-2 in innate immunity.
树突状细胞（DCs）在激活自然杀伤（NK）细胞中起主要作用，NK细胞发挥其针对病原体感染细胞和肿瘤细胞的功能。在此，我们使用小鼠模型来研究负责这一过程的分子机制。细菌激活的髓样DC产生的两种可溶性分子是NK细胞最佳启动所必需的。I型干扰素（IFNs）促进NK细胞的细胞毒性功能。IL-2在体外和体内对于高效产生IFNγ都是必需的，IFNγ具有重要的抗转移和抗菌功能。这些发现提供了关于介导DC-NK细胞相互作用机制的新信息，并确定了IL-2在先天免疫中的一种新的基本作用。
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