Boulu R, Plotkine M, Guéniau C, Rossignol P
C R Acad Hebd Seances Acad Sci D. 1977 Jan;284(3):239-42.
Oxygen tension (pO2) in cerebral cortex was measured by polarographic method in unanesthetized rabbits. Intravenous administration (25 mg/kg) of carbonic anhydrase inhibitors (acetazolamide, methazolamide, dichlorphenamide, sulthiame) induced an early important rise of cortical p O2, which is not dependent on increase of p O2 and p CO2 and decrease of pH in arterial blood. High dosage of acetazolamide (250 mg/kg) produced the same effect and did not suppress the increase of cortical p O2 under air-CO2 inhalation. This result suggests that CO2 might act specifically upon cerebral vessels.
采用极谱法在未麻醉的家兔中测量大脑皮质的氧分压（pO₂）。静脉注射（25mg/kg）碳酸酐酶抑制剂（乙酰唑胺、甲醋唑胺、二氯苯磺胺、舒噻美）可使皮质pO₂早期显著升高，这一升高不依赖于动脉血中pO₂升高、pCO₂降低及pH下降。高剂量乙酰唑胺（250mg/kg）产生相同效应，且在吸入空气-二氧化碳时不抑制皮质pO₂的升高。该结果提示，二氧化碳可能对脑血管有特异性作用。
