通过巢式广谱聚合酶链反应在一只黑猩猩粪便中检测到新型多瘤病毒。
Novel polyomavirus detected in the feces of a chimpanzee by nested broad-spectrum PCR.
作者信息
Johne Reimar, Enderlein Dirk, Nieper Hermann, Müller Hermann
机构信息
Institute for Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, D-04103 Leipzig, Germany.
出版信息
J Virol. 2005 Mar;79(6):3883-7. doi: 10.1128/JVI.79.6.3883-3887.2005.
Abstract
In order to screen for new polyomaviruses in samples derived from various animal species, degenerated PCR primer pairs were constructed. By using a nested PCR protocol, the sensitive detection of nine different polyomavirus genomes was demonstrated. The screening of field samples revealed the presence of a new polyomavirus, tentatively designated chimpanzee polyomavirus (ChPyV), in the feces of a juvenile chimpanzee (Pan troglodytes). Analysis of the region encoding the major capsid protein VP1 revealed a unique insertion in the EF loop of the protein and showed that ChPyV is a distinct virus related to the monkey polyomavirus B-lymphotropic polyomavirus and the human polyomavirus JC polyomavirus.
摘要
为了在源自各种动物物种的样本中筛选新的多瘤病毒，构建了简并PCR引物对。通过使用巢式PCR方案，证明了能灵敏检测九种不同的多瘤病毒基因组。对野外样本的筛查显示，在一只幼年黑猩猩（黑猩猩属）的粪便中存在一种新的多瘤病毒，暂命名为黑猩猩多瘤病毒（ChPyV）。对编码主要衣壳蛋白VP1的区域进行分析，发现该蛋白的EF环中有一个独特的插入序列，表明ChPyV是一种与猴多瘤病毒B淋巴细胞嗜性多瘤病毒和人多瘤病毒JC多瘤病毒相关的独特病毒。
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