Institute for Virology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
J Gen Virol. 2010 Dec;91(Pt 12):3016-22. doi: 10.1099/vir.0.023549-0. Epub 2010 Aug 25.
Polyomaviruses of birds are aetiological agents of acute inflammatory diseases in non-immunocompromised hosts, which is in contrast to mammalian polyomaviruses. VP4, an additional structural protein encoded by the viral genomes of the known avian polyomaviruses, has been suggested to contribute to pathogenicity through loss of cells following induction of apoptosis. Four distinct bird polyomaviruses have been identified so far, which infect crows, finches, geese and parrots. Using broad-spectrum PCR, a novel polyomavirus, tentatively designated canary polyomavirus (CaPyV), was detected in diseased canary birds (Serinus canaria) that died at an age of about 40 days. Intranuclear inclusion bodies were found in the liver, spleen and kidneys. The entire viral genome was amplified from a tissue sample using rolling-circle amplification. Phylogenetic analysis of the genome sequence indicated a close relationship between CaPyV and other avian polyomaviruses. Remarkably, an ORF encoding VP4 could not be identified in the CaPyV genome. Therefore, the mechanism of pathogenicity of CaPyV may be different from that of the other avian polyomaviruses.
鸟类多瘤病毒是未免疫宿主急性炎症疾病的病原体，这与哺乳动物多瘤病毒形成对比。已知的禽多瘤病毒的病毒基因组编码的另一种结构蛋白 VP4，通过诱导细胞凋亡导致细胞丢失，被认为有助于其致病性。迄今为止，已经鉴定出四种不同的禽多瘤病毒，它们感染乌鸦、雀类、鹅和鹦鹉。使用广谱 PCR，在年龄约为 40 天的病死金丝雀（Serinus canaria）中检测到一种新型多瘤病毒，暂定名为金丝雀多瘤病毒（CaPyV）。在肝脏、脾脏和肾脏中发现了核内包涵体。使用滚环扩增从组织样本中扩增出整个病毒基因组。基因组序列的系统发育分析表明 CaPyV 与其他禽多瘤病毒密切相关。值得注意的是，在 CaPyV 基因组中无法识别出编码 VP4 的 ORF。因此，CaPyV 的致病机制可能与其他禽多瘤病毒不同。
