Antonsson Annika, Hansson Bengt Göran
Department of Medical Microbiology, Malmö University Hospital, Lund University, SE-205 02 Malmö, Sweden.
J Virol. 2002 Dec;76(24):12537-42. doi: 10.1128/jvi.76.24.12537-12542.2002.
Papillomaviruses associated with clinical symptoms have been found in many vertebrate species. In this study, we have used an L1 gene consensus PCR test designed to detect a broad spectrum of human skin papillomaviruses to analyze swab samples from healthy skin of 111 animals belonging to 19 vertebrate species. In eight of the species, papillomavirus DNA was found with the following prevalences: chimpanzees, 9 of 11 samples positive; gorillas, 3 of 4; long-tailed macaques, 14 of 16; spider monkeys, 2 of 2; ruffed lemurs, 1 of 2; cows, 6 of 10; European elks, 4 of 4; aurochs, 1 of 1. In total, 53 new putative animal papillomavirus types were found. The results show that skin papillomaviruses can be detected in healthy skin from many different animal species and are sufficiently related genetically to their human counterparts to be identified by a human skin papillomavirus primer set (FAP59 and FAP64).
在许多脊椎动物物种中都发现了与临床症状相关的乳头瘤病毒。在本研究中，我们使用了一种旨在检测多种人类皮肤乳头瘤病毒的L1基因共识PCR检测方法，来分析来自19种脊椎动物物种的111只动物健康皮肤的拭子样本。在其中8个物种中发现了乳头瘤病毒DNA，其阳性率如下：黑猩猩，11个样本中有9个阳性；大猩猩，4个中有3个；食蟹猴，16个中有14个；蜘蛛猴，2个中有2个；黑白领狐猴，2个中有1个；牛，10个中有6个；欧洲驼鹿，4个中有4个；原牛，1个中有1个。总共发现了53种新的假定动物乳头瘤病毒类型。结果表明，在许多不同动物物种的健康皮肤中都能检测到皮肤乳头瘤病毒，并且它们在基因上与人类乳头瘤病毒有足够的相关性，能够被人类皮肤乳头瘤病毒引物组（FAP59和FAP64）识别。
