Morgello Susan
Department of Pathology (Neuropathology) Mount Sinai Medical Center, Box 1134, 1 Gustave L Levy Place, New York, NY 10029, USA.
Semin Liver Dis. 2005 Feb;25(1):118-21. doi: 10.1055/s-2005-864787.
Hepatitis C virus (HCV)-associated nervous system disorders have been described with increasing frequency in the literature, but definitive conclusions regarding their pathogenesis is for the most part lacking. Best established are complications due to cryoglobulinemia, vasculitis, and thrombosis, in which focal disturbances of peripheral nerve or brain function are seen. Rarer are cases of inflammatory encephalitis and/or myelitis similar to other flaviviral infections. A body of literature detailing cognitive abnormalities is accumulating; still unclear is whether these neuropsychologic effects are due specifically to HCV or to other processes associated with HCV infection. HCV has been localized to the central nervous system; much of its basic neurobiology remains to be described and awaits further correlation with clinical abnormalities.
丙型肝炎病毒（HCV）相关的神经系统疾病在文献中的描述越来越频繁，但关于其发病机制的明确结论大多仍未得出。最常见的并发症是冷球蛋白血症、血管炎和血栓形成，这些会导致周围神经或脑功能的局灶性障碍。与其他黄病毒感染相似的炎症性脑炎和/或脊髓炎病例则较为罕见。关于认知异常的文献越来越多；目前尚不清楚这些神经心理效应是特定由HCV引起的，还是与HCV感染相关的其他过程导致的。HCV已在中枢神经系统中定位；其许多基本神经生物学仍有待描述，并有待进一步与临床异常情况建立关联。
