[眼附属器MALT型淋巴瘤与反应性淋巴样增生的鉴别诊断研究]

[Study on differential diagnosis between MALT-type lymphoma and reactive lymphoid hyperplasia of the ocular adnexa].

作者信息

Xu Qing, Xiao Li-hua, He Yan-jin, Li Min, Li Ning, Gao Zi-fen

机构信息

Department of Ophthalmology, Armed Police General Hospital, Beijing 100039, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2004 Dec;40(12):795-9.

PMID:15733428

Abstract

OBJECTIVE

To study the methods of differential diagnosis between mucosa-associated lymphoid tissue (MALT) type lymphoma and reactive lymphoid hyperplasia in ocular adnexa.

METHODS

The clinical, morphologic, immunohistochemical, and molecular biologic (polymerase chain reaction [PCR]) studies were performed on 29 patients with MALT-type lymphoma and 8 patients with reactive lymphoid hyperplasia of the ocular adnexa.

RESULTS

29 cases with MALT-type lymphoma expressed B-cell markers and but T-cell makers, whereas 8 cases of reactive lymphoid hyperplasia all expressed B and T cell markers and the positive rate of T-cell marker was up to 30%. immunohistochemistry staining showed 11 cases were positive for immunoglobin light chain (kappa or lambda), however it was positive in one chain of the immunoglobin in 15 cases of MALT type lymphoma by PCR. No significant difference in the clinical characteristics was observed between the MALT type lymphoma and reactive lymphoid hyperplasia in ocular adnexa.

CONCLUSION

Immunohistochemical analysis and PCR are helpful in confirming the diagnosis between the MALT-lymphoma and the reactive lymphoid hyperplasia.

摘要

目的

研究眼附属器黏膜相关淋巴组织（MALT）型淋巴瘤与反应性淋巴组织增生的鉴别诊断方法。

方法

对29例眼附属器MALT型淋巴瘤患者和8例眼附属器反应性淋巴组织增生患者进行临床、形态学、免疫组织化学及分子生物学（聚合酶链反应[PCR]）研究。

结果

29例MALT型淋巴瘤表达B细胞标志物而非T细胞标志物，而8例反应性淋巴组织增生均表达B和T细胞标志物，T细胞标志物阳性率达30%。免疫组织化学染色显示11例免疫球蛋白轻链（κ或λ）阳性，然而通过PCR检测，15例MALT型淋巴瘤中有1例免疫球蛋白的一条链呈阳性。眼附属器MALT型淋巴瘤与反应性淋巴组织增生在临床特征上未观察到显著差异。