马缨丹（马鞭草科）对大鼠一般生殖性能和致畸学的影响。

Effects of Lantana camara (Verbenaceae) on general reproductive performance and teratology in rats.

作者信息

Mello Fernanda B, Jacobus Daniela, Carvalho Kelly, Mello João R B

机构信息

Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul, UFRGS, Av. Sarmento Leite n. 500, sala 202, Porto Alegre, RS, 90046-900, Brazil.

出版信息

Toxicon. 2005 Mar 15;45(4):459-66. doi: 10.1016/j.toxicon.2004.12.004.

DOI:10.1016/j.toxicon.2004.12.004

PMID:15733567

Abstract

Lantana camara L. (Verbenaceae) possesses several medicinal properties and it is used in folk medicine with antipyretic, antimicrobial and antimutagenic properties. This plant is one of the 10 most noxious weeds in the world. Lantana poisoning have caused severe economic losses and was the major cause of livestock mortality and morbidity. In this article we report the effects of hydroalcoholic extract from Lantana camara var. aculeata leaves on fertility, general reproductive performance and teratology in the rat. The data showed that the extract interfered in the frequency of fetal skeleton anomalies from dams treated with the extract and induced embryotoxicity as indicated by post-implantation loss, without any signs of maternal toxicity. The other parameters evaluated did not suggest modifications.

摘要

马缨丹（马鞭草科）具有多种药用特性，在民间医学中用于退热、抗菌和抗诱变。这种植物是世界上10种最有害的杂草之一。马缨丹中毒已造成严重的经济损失，是牲畜死亡和发病的主要原因。在本文中，我们报告了马缨丹变种尖刺叶的水醇提取物对大鼠生育力、一般生殖性能和致畸学的影响。数据显示，提取物干扰了用提取物处理的母鼠胎儿骨骼异常的频率，并如着床后损失所示诱导了胚胎毒性，且没有任何母体毒性迹象。评估的其他参数未显示有变化。