Saini N, Singh J, Sehgal R, Ojha S
Department of Hepatology, Postgraduate Institute of Medical Education & Research, Panjab University, Chandigarh, India.
Cell Mol Biol (Noisy-le-grand). 2007 May 30;53(5):79-83.
Lantana camara is a common weed and certain medicinal properties have been attributed to this plant, but most varieties of this plant are reported to be highly toxic to animals. The plant is a native of America but a few varieties are indigenous to tropical Asia and Africa. The present investigation was done to study the hepatotoxic and lipid peroxidative effects of this noxious weed on female Wistar rats. Eighty four percent (84%) increase was observed in the activity of AST in group B and 120% increase was noted in group C in serum. In, liver tissue this increase was 66% and 258%. In the case of ALT, 165% increase was observed in group B and 219% increase was observed in group C in serum. In, liver there was 46% increase in group B and 216% increase in group C in the ALT activity. Similarly, 30% and 50% increase in group B and 120% and 300% increase in group C in the activity of ALP was observed with respect to control group. The overall protein concentration was increased in serum and decreased in liver tissue. Lipid peroxidation in liver tissue was inhibited by 22% in group B and 55% in group C. Thus Lantana camara is a toxic plant which produces severe hepatotoxicity in rats, but it also prevented lipid peroxidation that may suggest that Lantana camara may be acting as antioxidant but, exactly which of its component is responsible for this activity is not known and needs future investigations.
马缨丹是一种常见杂草，人们认为这种植物具有某些药用特性，但据报道该植物的大多数品种对动物具有高毒性。这种植物原产于美洲，但少数品种原产于热带亚洲和非洲。本研究旨在探讨这种有害杂草对雌性Wistar大鼠的肝毒性和脂质过氧化作用。B组血清中AST活性增加了84%，C组增加了120%。在肝脏组织中，这一增加分别为66%和258%。就ALT而言，B组血清中ALT活性增加了165%，C组增加了219%。在肝脏中，B组ALT活性增加了46%，C组增加了216%。同样，与对照组相比，B组ALP活性增加了30%和50%，C组增加了120%和300%。血清中总蛋白浓度升高，肝脏组织中总蛋白浓度降低。B组肝脏组织中的脂质过氧化受到22%的抑制，C组受到55%的抑制。因此，马缨丹是一种有毒植物，可在大鼠中产生严重的肝毒性，但它也能防止脂质过氧化，这可能表明马缨丹可能具有抗氧化作用，但其究竟是哪种成分导致了这种活性尚不清楚，需要未来进一步研究。
