Department of Pharmacology, Ultra College of Pharmacy, Madurai, India.
J Ethnopharmacol. 2011 Mar 8;134(1):195-7. doi: 10.1016/j.jep.2010.11.049. Epub 2010 Dec 1.
Lantana camara L. (Verbenaceae), a widely growing shrub has been used in the traditional medicine for treating many ailments. The objective of the present study was to evaluate the effects of methanolic extract of Lantana camara leaves on gastric and duodenal ulcers.
The antiulcerogenic effect of methanolic extract of Lantana camara was evaluated in aspirin induced gastric ulcerogenesis in pyloric ligated rats, ethanol induced gastric ulcer, and cysteamine induced duodenal ulcer models. The extract was administered orally at two different doses of 250 mg/kg and 500 mg/kg. The lipid peroxidation, reduced glutathione levels of ethanol induced gastric ulcer model and inhibition zone in diameter against Helicobacter pylori also determined.
The L. camara extract significantly (P<0.01) reduced ulcer index, total acidity and significantly (P<0.01) increased the gastric pH of aspirin+pylorus-ligation induced ulcerogenesis and ethanol induced gastric ulcer models. The extract also significantly (P<0.01) reduced the ulcer index of cysteamine induced duodenal ulcer. The L. camara showed significant (P<0.01) reduction in lipid peroxidation and increase in reduced glutathione levels. The inhibition zone in diameter of extract against H. pylori was 20mm.
The methanolic extract of Lantana camara leaves shown healing of gastric ulcers and also prevents development of duodenal ulcers in rats.
马缨丹（马鞭草科），一种广泛生长的灌木，已被用于传统医学治疗许多疾病。本研究的目的是评估马缨丹叶甲醇提取物对胃和十二指肠溃疡的影响。
采用阿司匹林诱导的幽门结扎大鼠胃溃疡模型、乙醇诱导的胃溃疡和半胱胺诱导的十二指肠溃疡模型评价马缨丹甲醇提取物的抗溃疡作用。提取物以 250mg/kg 和 500mg/kg 两种不同剂量口服给药。还测定了乙醇诱导的胃溃疡模型的脂质过氧化、还原型谷胱甘肽水平和对幽门螺杆菌的抑制圈直径。
马缨丹提取物显著降低了阿司匹林+幽门结扎诱导的溃疡形成和乙醇诱导的胃溃疡模型的溃疡指数、总酸度，并显著增加了胃 pH 值。该提取物还显著降低了半胱胺诱导的十二指肠溃疡的溃疡指数。马缨丹显著降低了脂质过氧化，增加了还原型谷胱甘肽水平。提取物对幽门螺杆菌的抑制圈直径为 20mm。
马缨丹叶甲醇提取物具有治疗胃溃疡的作用，还可预防大鼠十二指肠溃疡的发生。
