Harbishettar Vijaykumar, Pal Pramod Kumar, Janardhan Reddy Y C, Thennarasu K
Department of Psychiatry, National Institute of Mental Health and Neuroscience, Bangalore 560029, Karnataka, India.
Parkinsonism Relat Disord. 2005 Mar;11(2):85-8. doi: 10.1016/j.parkreldis.2004.07.006.
Obsessive-compulsive (OC) symptoms and obsessive-compulsive disorder (OCD) have been reported in Parkinson's disease (PD). This is interpreted as an indirect evidence for the involvement of frontobasal ganglia circuitry in OCD. However, the evidence for relationship between the OC symptoms and PD is inconsistent. This study systematically assessed OC symptoms and OCD in non-demented idiopathic PD patients (n=69) and matched medically ill controls (n=69). The cases did not differ from controls with respect to OC symptoms, clinical and subclinical OCD, tics and other psychiatric diagnoses. There was no relationship between severity of PD and OC symptoms. The findings do not support relationship between OCD and PD. While the findings of this study do not in any way rule out the involvement of frontobasal ganglia circuitry in OCD, it is speculated that the involvement of different circuitry in the pathophysiology of OCD and PD explain the lack of association between PD and OCD.
帕金森病（PD）患者中已报告存在强迫（OC）症状和强迫症（OCD）。这被解释为额叶基底神经节回路参与强迫症的间接证据。然而，OC症状与PD之间关系的证据并不一致。本研究系统评估了非痴呆特发性PD患者（n = 69）和匹配的内科疾病对照者（n = 69）的OC症状和OCD。病例在OC症状、临床和亚临床OCD、抽动及其他精神科诊断方面与对照者无差异。PD严重程度与OC症状之间无关联。这些发现不支持OCD与PD之间存在关系。虽然本研究结果绝不能排除额叶基底神经节回路参与强迫症，但据推测，强迫症和帕金森病病理生理学中不同回路的参与解释了帕金森病与强迫症之间缺乏关联的原因。
