Ashtekar M D, Samuel A M, Kameswaran M, Kadival G V, Sakhalkar V, Rajadhyaksha S
Radiation Medicine Centre, Bhabha Atomic Research Centre, Parel, Bombay, India.
J Trop Pediatr. 1992 Feb;38(1):22-6. doi: 10.1093/tropej/38.1.22.
A radioimmunoassay for the detection of tubercular (TB) antigen (Ag) and antitubercular antibody (Ab) was evaluated for the serodiagnosis of childhood tuberculosis. Children with primary complex, progressive primary complex, miliary tuberculosis, and calcified lung lesions without clinical evidence of active tuberculosis were studied. Significantly elevated levels of TB Ag and TB Ab isolated from the circulating immune complexes were obtained in primary, progressive primary, and miliary tuberculosis patients as compared to controls (P less than 0.01). The majority of patients with calcified lung lesions and without active tuberculosis demonstrated high levels of antibody. It was observed that elevated levels of TB Ag and/or antibodies were present in 54 per cent of patients with primary complex, 94 per cent of patients with progressive disease and 69 per cent of patients with miliary tuberculosis. It is possible that is suspected patients with the above mentioned diseases, a diagnosis can be established by using these techniques.
一种用于检测结核（TB）抗原（Ag）和抗结核抗体（Ab）的放射免疫分析法被用于儿童结核病的血清学诊断评估。对患有原发性复合征、进行性原发性复合征、粟粒性结核病以及有钙化肺病变但无活动性结核病临床证据的儿童进行了研究。与对照组相比，原发性、进行性原发性和粟粒性结核病患者从循环免疫复合物中分离出的TB Ag和TB Ab水平显著升高（P小于0.01）。大多数有钙化肺病变且无活动性结核病的患者显示出高水平的抗体。据观察，原发性复合征患者中有54%、进展性疾病患者中有94%以及粟粒性结核病患者中有69%的患者TB Ag和/或抗体水平升高。对于疑似患有上述疾病的患者，有可能通过使用这些技术来确立诊断。
