Van Dyke Thomas E, Sheilesh Dave
Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, MA 02118, USA.
J Int Acad Periodontol. 2005 Jan;7(1):3-7.
In recent years, it has become apparent that the pathogenesis of periodontal diseases is more complex than the presence of virulent microorganisms. In fact, it is now widely accepted that susceptibility to periodontitis varies greatly between individuals who harbor the same pathogenic microflora. To date, the bulk of evidence points to the host response to bacterial challenge as a major determinant of susceptibility. In this review, we will assess the data implicating various inherited and acquired risk factors for susceptibility to periodontal diseases.
近年来，很明显牙周疾病的发病机制比致病性微生物的存在更为复杂。事实上，现在人们普遍认为，在携带相同致病微生物群落的个体之间，对牙周炎的易感性差异很大。迄今为止，大量证据表明宿主对细菌攻击的反应是易感性的主要决定因素。在这篇综述中，我们将评估涉及牙周疾病易感性的各种遗传和后天风险因素的数据。
