Jaber J R, Pérez J, Carballo M, Arbelo M, Espinosa de los Monteros A, Herráez P, Muñoz J, Andrada M, Rodríguez F, Fernández A
Departamento de Morfología, Facultad de Veterinaria de Las Palmas de Gran Canaria, Las Palmas, Spain.
J Comp Pathol. 2005 Feb-Apr;132(2-3):242-7. doi: 10.1016/j.jcpa.2004.09.009.
This report describes a large cell immunoblastic lymphoma in a bottlenose dolphin found stranded alive in Gran Canaria, Spain. Diffuse infiltration of round neoplastic cells was observed in the splenic cords and sinuses and in hepatic sinusoids, resulting in moderate organ enlargement. The tumour cells (immunophenotype IgG+ and CD3-) showed scant, lightly eosinophilic or basophilic cytoplasm, distinct cell boundaries and hyperchromatic nuclei, each with one or more nucleoli. Mitoses were common. On the basis of histopathological, immunohistochemical and ultrastructural features, the tumour was classified as an immunoblastic lymphoma. Eleven polychlorinated biphenyl (PCB) congeners, 23 organochlorine pesticides and 16 polycyclic aromatic hydrocarbons (PAHs) were detected in the blubber and liver. High concentrations of PCBs 153, 180, 138 and 187 found in the liver may have been associated with the hepatosplenic lymphoma.
本报告描述了一头在西班牙大加那利岛搁浅时仍存活的宽吻海豚身上的大细胞免疫母细胞性淋巴瘤。在脾索、脾窦以及肝血窦中观察到圆形肿瘤细胞的弥漫性浸润，导致器官中度肿大。肿瘤细胞（免疫表型为IgG+和CD3-）胞质稀少，轻度嗜酸性或嗜碱性，细胞边界清晰，细胞核染色质增多，每个细胞核有一个或多个核仁。有丝分裂常见。根据组织病理学、免疫组织化学和超微结构特征，该肿瘤被分类为免疫母细胞性淋巴瘤。在鲸脂和肝脏中检测到11种多氯联苯（PCB）同系物、23种有机氯农药和16种多环芳烃（PAH）。在肝脏中发现的高浓度多氯联苯153、180、138和187可能与肝脾淋巴瘤有关。
