阿片类药物与神经性疼痛：来自动物研究的线索。
Opioids in neuropathic pain: clues from animal studies.
作者信息
Dickenson Anthony H, Suzuki Rie
机构信息
Department of Pharmacology, University College, Gower Street, London WC1E 6BT, UK.
出版信息
Eur J Pain. 2005 Apr;9(2):113-6. doi: 10.1016/j.ejpain.2004.05.004.
PMID:15737797
Abstract
For many years the clinical consensus was that opioids were ineffective in neuropathic pain. However this view is changing and here we discuss the mechanisms of opioid analgesia in terms of the changes that can occur in preclinical models of nerve injury. We argue that opioid mechanisms can be perturbed by neuropathy but in most cases these negative influences can be overcome by dose-escalation.
摘要
多年来，临床共识一直认为阿片类药物对神经性疼痛无效。然而，这种观点正在改变，在此我们将根据神经损伤临床前模型中可能发生的变化来讨论阿片类药物镇痛的机制。我们认为，阿片类药物的作用机制可能会受到神经病变的干扰，但在大多数情况下，这些负面影响可以通过增加剂量来克服。
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