生酮饮食与疼痛。
Ketogenic diets and pain.
作者信息
Masino Susan A, Ruskin David N
机构信息
Neuroscience Program and Department of Psychology, Trinity College, Hartford, CT 06106, USA.
出版信息
J Child Neurol. 2013 Aug;28(8):993-1001. doi: 10.1177/0883073813487595. Epub 2013 May 16.
Abstract
Ketogenic diets are well established as a successful anticonvulsant therapy. Based on overlap between mechanisms postulated to underlie pain and inflammation, and mechanisms postulated to underlie therapeutic effects of ketogenic diets, recent studies have explored the ability for ketogenic diets to reduce pain. Here we review clinical and basic research thus far exploring the impact of a ketogenic diet on thermal pain, inflammation, and neuropathic pain.
摘要
生酮饮食作为一种成功的抗惊厥疗法已被广泛认可。基于推测的疼痛和炎症潜在机制与推测的生酮饮食治疗效果潜在机制之间的重叠，最近的研究探讨了生酮饮食减轻疼痛的能力。在此，我们综述了迄今为止探索生酮饮食对热痛、炎症和神经性疼痛影响的临床和基础研究。
相似文献
1
Ketogenic diets and pain.生酮饮食与疼痛。
J Child Neurol. 2013 Aug;28(8):993-1001. doi: 10.1177/0883073813487595. Epub 2013 May 16.
2
Ketogenic diets and thermal pain: dissociation of hypoalgesia, elevated ketones, and lowered glucose in rats.生酮饮食与热痛：大鼠镇痛作用降低、酮体升高和血糖降低的分离现象。
J Pain. 2013 May;14(5):467-74. doi: 10.1016/j.jpain.2012.12.015. Epub 2013 Mar 15.
3
Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.给予生酮饮食的幼年和成年大鼠可减轻疼痛和炎症。
PLoS One. 2009 Dec 23;4(12):e8349. doi: 10.1371/journal.pone.0008349.
4
Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents.生酮饮食对啮齿动物炎症性触诱发痛和持续性疼痛的影响。
Sci Rep. 2021 Jan 12;11(1):725. doi: 10.1038/s41598-020-80727-x.
5
A ketogenic diet reduces long-term potentiation in the dentate gyrus of freely behaving rats.生酮饮食可降低自由活动大鼠齿状回的长期增强现象。
J Neurophysiol. 2011 Aug;106(2):662-6. doi: 10.1152/jn.00001.2011. Epub 2011 May 25.
6
Some Musings About Differential Energy Metabolism With Ketogenic Diets.关于生酮饮食的差异化能量代谢的一些思考。
JPEN J Parenter Enteral Nutr. 2019 Jul;43(5):578-582. doi: 10.1002/jpen.1665. Epub 2019 Jun 5.
7
The case for a ketogenic diet in the management of kidney disease.生酮饮食在肾脏疾病管理中的应用依据
BMJ Open Diabetes Res Care. 2024 Apr 27;12(2):e004101. doi: 10.1136/bmjdrc-2024-004101.
8
The emerging role of ketogenic diets in cancer treatment.生酮饮食在癌症治疗中的新作用。
Curr Opin Clin Nutr Metab Care. 2019 Mar;22(2):129-134. doi: 10.1097/MCO.0000000000000540.
9
The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms.生酮饮食对癫痫发作的抗惊厥作用及其潜在机制。
Curr Neuropharmacol. 2018;16(1):66-70. doi: 10.2174/1570159X15666170517153509.
10
An acidosis-sparing ketogenic (ASK) diet to improve efficacy and reduce adverse effects in the treatment of refractory epilepsy.一种节省酸中毒的生酮（ASK）饮食，用于提高难治性癫痫治疗的疗效并减少不良反应。
Epilepsy Behav. 2017 Sep;74:15-21. doi: 10.1016/j.yebeh.2017.05.032. Epub 2017 Jun 28.
引用本文的文献
1
Unlocking Hope: Development of India's First Indigenous Ketogenic Dietary Formula for Pediatric Epilepsy Care.开启希望：印度首款用于小儿癫痫护理的本土生酮饮食配方的研发
Ann Indian Acad Neurol. 2025 Jul 1;28(4):541-546. doi: 10.4103/aian.aian_155_25. Epub 2025 Jun 9.
2
MCT-modified ketogenic diet as an adjunct to standard treatment regimen could alleviate clinical symptoms in women with endometriosis.中链甘油三酯改良生酮饮食作为标准治疗方案的辅助手段，可缓解子宫内膜异位症女性的临床症状。
BMC Womens Health. 2025 May 16;25(1):232. doi: 10.1186/s12905-025-03798-w.
3
Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma.胶质母细胞瘤生酮代谢疗法的临床研究框架提案
BMC Med. 2024 Dec 5;22(1):578. doi: 10.1186/s12916-024-03775-4.
4
Protocol for a randomized comparative effectiveness trial comparing a very low-carbohydrate diet to DASH diet for polycystic ovary syndrome: the SUPER (Supporting Understanding of PCOS Education and Research) trial.一项将极低碳水化合物饮食与得舒饮食用于多囊卵巢综合征的随机比较有效性试验方案：SUPER（支持多囊卵巢综合征教育与研究理解）试验
Trials. 2024 Nov 9;25(1):750. doi: 10.1186/s13063-024-08583-y.
5
Ketogenic Diet: A Review of Composition Diversity, Mechanism of Action and Clinical Application.生酮饮食：组成多样性、作用机制及临床应用综述
J Nutr Metab. 2024 Oct 18;2024:6666171. doi: 10.1155/2024/6666171. eCollection 2024.
6
Time-restricted ketogenic diet in amyotrophic lateral sclerosis: a case study.肌萎缩侧索硬化症的限时生酮饮食：一项病例研究。
Front Neurol. 2024 Jan 18;14:1329541. doi: 10.3389/fneur.2023.1329541. eCollection 2023.
7
Modified Mediterranean-Ketogenic Diet and Carboxytherapy as Personalized Therapeutic Strategies in Lipedema: A Pilot Study.改良地中海生酮饮食和羧基疗法作为脂肪水肿的个性化治疗策略：一项初步研究。
Nutrients. 2023 Aug 20;15(16):3654. doi: 10.3390/nu15163654.
8
Efficacy, safety and tolerability of very low-calorie ketogenic diet in obese women with fibromyalgia: a pilot interventional study.极低热量生酮饮食对肥胖纤维肌痛女性的疗效、安全性和耐受性：一项试点干预研究。
Front Nutr. 2023 Jul 12;10:1219321. doi: 10.3389/fnut.2023.1219321. eCollection 2023.
9
Protocol for a randomized controlled trial comparing a very low-carbohydrate diet or moderate-carbohydrate plate-method diet for type 2 diabetes: the LEGEND (Lifestyle Education about Nutrition for Diabetes) trial.2 型糖尿病患者极低碳水化合物饮食或中碳水化合物餐盘法饮食比较的随机对照试验方案：LEGEND（糖尿病营养生活教育）试验。
Trials. 2023 Jul 20;24(1):463. doi: 10.1186/s13063-023-07512-9.
10
Habituation to Pain in Patients with Chronic Pain: Clinical Implications and Future Directions.慢性疼痛患者对疼痛的习惯化：临床意义及未来方向
J Clin Med. 2023 Jun 27;12(13):4305. doi: 10.3390/jcm12134305.
本文引用的文献
1
Ketogenic diets and thermal pain: dissociation of hypoalgesia, elevated ketones, and lowered glucose in rats.生酮饮食与热痛：大鼠镇痛作用降低、酮体升高和血糖降低的分离现象。
J Pain. 2013 May;14(5):467-74. doi: 10.1016/j.jpain.2012.12.015. Epub 2013 Mar 15.
2
Genomic responses in mouse models poorly mimic human inflammatory diseases.小鼠模型中的基因组反应与人类炎症性疾病的反应相差很大。
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12. doi: 10.1073/pnas.1222878110. Epub 2013 Feb 11.
3
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.高强度游泳运动减轻复杂性区域疼痛综合征 I 型动物模型中的神经性疼痛：涉及腺苷能系统的作用证据。
Neuroscience. 2013 Mar 27;234:69-76. doi: 10.1016/j.neuroscience.2012.12.042. Epub 2013 Jan 3.
4
Traditional acupuncture triggers a local increase in adenosine in human subjects.传统针灸会引起人体局部腺苷的增加。
J Pain. 2012 Dec;13(12):1215-23. doi: 10.1016/j.jpain.2012.09.012.
5
Seizures in Alzheimer disease: clinical and epidemiological data.阿尔茨海默病中的癫痫发作：临床和流行病学数据。
Epilepsy Curr. 2012 Sep;12(5):184-7. doi: 10.5698/1535-7511-12.5.184.
6
Obesity and metabolic syndrome and functional and structural brain impairments in adolescence.青少年肥胖、代谢综合征与大脑功能和结构损伤
Pediatrics. 2012 Oct;130(4):e856-64. doi: 10.1542/peds.2012-0324. Epub 2012 Sep 3.
7
Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease.低碳水化合物生酮饮食、葡萄糖稳态和非酒精性脂肪肝病。
Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):374-80. doi: 10.1097/MCO.0b013e3283547157.
8
Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis.炎症介导的记忆功能障碍及生酮饮食对多发性硬化症小鼠模型的影响。
PLoS One. 2012;7(5):e35476. doi: 10.1371/journal.pone.0035476. Epub 2012 May 2.
9
The ketogenic diet as a treatment paradigm for diverse neurological disorders.生酮饮食作为多种神经系统疾病的治疗模式。
Front Pharmacol. 2012 Apr 9;3:59. doi: 10.3389/fphar.2012.00059. eCollection 2012.
10
The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy.神经系统与代谢失调：越来越多的证据表明生酮饮食疗法与之相关。
Front Neurosci. 2012 Mar 26;6:33. doi: 10.3389/fnins.2012.00033. eCollection 2012.
Zotero 插件