Harlow S P, Duda R B, Bauer K D
Department of Surgery, Northwestern University, McGaw Medical Center, Chicago, Illinois.
J Surg Oncol. 1992 May;50(1):1-6. doi: 10.1002/jso.2930500102.
Preoperative diagnosis of follicular carcinoma of the thyroid remains a clinical challenge. This study determined the DNA content parameters of ploidy and proliferative activity levels from cells of normal thyroid tissue, follicular adenomas, and follicular carcinomas to evaluate if these parameters could be used as an adjunct to fine needle aspiration in their diagnosis. Statistically significant higher proliferative activity levels were found in the carcinoma groups (mean S-phase fraction [SPF] = 5.0%) compared to 2.9% for follicular adenomas and 1.3% for normal thyroid. DNA aneuploidy was identified in 73% of carcinomas and 36% of adenomas. Because of overlap of SPF values between groups, one could not rule out the presence or absence of malignancy based on DNA content parameters alone. These measurements may, however, be an aid to the decision making in patients who are poor surgical risks.
甲状腺滤泡癌的术前诊断仍是一项临床挑战。本研究测定了正常甲状腺组织、滤泡性腺瘤和滤泡癌组织细胞的DNA含量参数（倍性和增殖活性水平），以评估这些参数是否可用作细针穿刺活检诊断的辅助手段。结果发现，癌组织组的增殖活性水平在统计学上显著高于滤泡性腺瘤组（平均S期分数[SPF]=5.0%）和正常甲状腺组（1.3%）。73%的癌组织和36%的腺瘤组织存在DNA非整倍体现象。由于各组间SPF值存在重叠，因此不能仅根据DNA含量参数来判断是否存在恶性肿瘤。然而，对于手术风险较高的患者，这些测量结果可能有助于决策。
