Christov K
Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;51(3):255-63. doi: 10.1007/BF02899035.
By means of flow cytometry (FCM), DNA distribution pattern and the fraction of cells in the various phases of the cell cycle were studied in 52 samples of normal thyroid tissues, follicular adenomas, follicular carcinomas, medullary carcinoma and fibrosarcomas. In the normal thyroid tissues and follicular adenomas DNA diploid cell populations only were found. Among 20 follicular carcinomas in 13 cases (65%) together with the DNA diploid cells, DNA aneuploid cell lines were also observed. S-phase fraction in follicular adenomas is higher than in the normal thyroid tissues and lower than those in thyroid carcinomas. The percentage of S-phase cells in DNA aneuploid populations is significantly higher (S = 19 +/- 9.3%) than in the diploid cell lines (S = 3.7 +/- 2.6%). DNA aneuploid cell populations were predominantly observed in carcinomas with a high degree of morphological anaplasia.
通过流式细胞术（FCM），对52份正常甲状腺组织、滤泡性腺瘤、滤泡性癌、髓样癌和纤维肉瘤样本的DNA分布模式及细胞周期各阶段的细胞比例进行了研究。在正常甲状腺组织和滤泡性腺瘤中仅发现了DNA二倍体细胞群。在20例滤泡性癌中，13例（65%）除DNA二倍体细胞外，还观察到了DNA非整倍体细胞系。滤泡性腺瘤的S期比例高于正常甲状腺组织，低于甲状腺癌。DNA非整倍体群体中S期细胞的百分比（S = 19±9.3%）显著高于二倍体细胞系（S = 3.7±2.6%）。DNA非整倍体细胞群主要见于形态学上高度间变的癌组织中。
