一名患者使用拉莫三嗪可能出现白细胞减少和血小板减少。

Leucopenia and thrombocytopenia possibly associated with lamotrigine use in a patient.

作者信息

Ural Ali Ugur, Avcu Ferit, Gokcil Zeki, Nevruz Oral, Cetin Turker

机构信息

Department of Haematology, Medical and Cancer Research Center, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.

出版信息

Epileptic Disord. 2005 Mar;7(1):33-5.

PMID:15741138

Abstract

Haematological side effects are rather exceptional with lamotrigine. We report the case of a 25-year-old woman with epilepsy who developed combined leucopenia and thrombocytopenia eight weeks after starting lamotrigine. Within weeks after lamotrigine was discontinued, all of the haematopoietic abnormalities had disappeared. To our knowledge, this is the first report of combined leucopenia and thrombocytopenia associated with lamotrigine treatment suggesting, in our patient, a causal reaction.

摘要

拉莫三嗪的血液学副作用相当罕见。我们报告一例25岁癫痫女性患者，在开始服用拉莫三嗪8周后出现白细胞减少和血小板减少。在停用拉莫三嗪后的几周内，所有造血异常均消失。据我们所知，这是第一例与拉莫三嗪治疗相关的白细胞减少和血小板减少合并的报告，提示在我们的患者中存在因果反应。